Hypertension:早发性高血压与中年高血压终末器官损害有关

2019-07-02 xing.T MedSci原创

该研究结果强调了评估高血压患者高血压发病年龄的重要性,以确定高血压并发症的高危人群。

早发性高血压会增加社区心血管死亡的风险。早发性高血压是否也促进终末器官损害(TOD)的发生发展,即使在中年人中也尚未明确。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员分析了2680名中年CARDIA(年轻人的冠状动脉风险发展)研究的参与者(平均年龄50±4岁,57%为女性),他们在1985年至2011年间接受了多达8次连续血压测量(基线年龄范围18-30岁),此外在2010年至2011年期间进行了超声心动图检查评估左心室肥厚、冠状动脉钙化、白蛋白尿和舒张功能障碍。高血压发病年龄定义为连续2次参加检查血压≥140/90mmHg或使用抗高血压药物的年龄。参与者按高血压发病年龄(<35岁、35-44岁、≥45岁或无高血压)分组。在调整TOD危险因素(包括收缩压)时,研究人员使用Logistic回归来计算病例(TOD参与者)与对照者(没有TOD的参与者)之间的比值比,以评估高血压发病年龄与高血压TOD之间的关系。

与正常血压个体相比,高血压发病年龄<35岁的患者发生左心室肥大、冠状动脉钙化、白蛋白尿和舒张功能障碍相应比值比分别为2.29(95%CI为1.36-3.86)、2.94(95%CI为1.57-5.49)、1.12(95%CI为0.55-2.29)和2.06(95%CI为1.04-4.05)。相反,高血压发病年龄≥45岁与TOD增加的几率无关。

该研究结果强调了评估高血压患者高血压发病年龄的重要性,以确定高血压并发症的高危人群。 

原始出处:

Karri Suvila.et al.Early Onset Hypertension Is Associated With Hypertensive End-Organ Damage Already by MidLife.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13069

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likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jul 03 22:33:19 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368900, encodeId=e501368900e5, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1062346830, createdName=15122a1c63m, createdTime=Wed Jul 03 13:57:36 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368897, encodeId=404036889e4c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jul 03 12:46:56 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368858, encodeId=c8473688586d, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/04/2540fb84decb81d47a7f2868070e6cbd.jpg, createdBy=ed3f2205793, createdName=百草, createdTime=Tue Jul 02 23:35:23 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368848, encodeId=56103688483e, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-10-10 feather89
  5. 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
  6. 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likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jul 03 22:33:19 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368900, encodeId=e501368900e5, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1062346830, createdName=15122a1c63m, createdTime=Wed Jul 03 13:57:36 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368897, encodeId=404036889e4c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-07-03 qingfengqishi5

    学习了,学习了

    0

  7. 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likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jul 03 22:33:19 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368900, encodeId=e501368900e5, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c1062346830, createdName=15122a1c63m, createdTime=Wed Jul 03 13:57:36 CST 2019, time=2019-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368897, encodeId=404036889e4c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-07-03 15122a1c63m

    不错

    0

  8. 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-07-03 1209e435m98(暂无昵称)

    学习了

    0

  9. 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-07-02 百草

    666

    0

  10. 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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Tue Jul 02 22:05:39 CST 2019, time=2019-07-02, status=1, ipAttribution=)]
    2019-07-02 329523732

    不错

    0