JAMA Otolaryngol Head Neck Surg:酸反流可以引发上呼吸消化道肿瘤?

2018-01-09 慧语 肿瘤资讯

多数人都有过酸反流的经历,主要症状是胃灼热,感觉就像胸口有东西在燃烧,你也可能会在口中感受到不愉快的酸味。2017年12月21号,在线发表在《JAMA Otolaryngol Head Neck Surg》上的一项回顾性研究数据发现,胃食管反流病可能会增加老年人上呼吸消化道癌症的风险。

多数人都有过酸反流的经历,主要症状是胃灼热,感觉就像胸口有东西在燃烧,你也可能会在口中感受到不愉快的酸味。2017年12月21号,在线发表在《JAMA Otolaryngol Head Neck Surg》上的一项回顾性研究数据发现,胃食管反流病可能会增加老年人上呼吸消化道癌症的风险。

这是由美国新奥尔良Ochsner临床基金会主导的一项回顾性病例对照研究,观察数据来自美国监测、流行病学和结果(SEER)数据库,纳入2003年1月-2011年12月诊治的66岁以上的上呼吸消化道癌症患者13805名,依据年龄、性别两个因素匹配未患癌的对照组患者13805名。

研究人员发现,与没有胃食管反流病的人相比,有胃食管反流症状的老年人患上呼吸消化道癌症的风险平均要高出两倍以上。其中胃酸反流与发生喉癌的关联最强(OR=2.86,95%CI,2.65-3.09),与鼻窦癌的关系最弱(OR=1.40,95%CI,1.15-1.70)。提示对于已经有胃酸反流症状的患者,密切随访和早期干预可能是有必要的。此研究的局限性是,没有考虑饮酒和吸烟两个混杂因素的影响。所以这项结果并不能证明胃酸反流与发生上呼吸消化道癌症的因果关联,但此发现提示,如果一个人长期习惯性出现酸反流,就需引起重视了,要及时咨询医生。

英国癌症研究中心的Jasmine医生表示:目前尚不清楚患有酸反流是否会增加上呼吸消化道癌症的风险。这项研究确实发现两者具有相关性,但这仅仅是一个统计学关联,尚缺乏机制学的证实。而且此研究没有排除颈部肿瘤的高危混杂因素,如吸烟和饮酒,所以尚无法确证酸反流是上呼吸消化道癌症发生的独立危险因素。

虽然此项研究结果的证据级别有限,但是酸回流如果持续或异常的发生,绝对不是一个好信号。

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    2018-01-15 虈亣靌

    不错的文章值得推荐

    0

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    2018-01-11 feifers
  4. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Wed Jan 10 16:39:03 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277154, encodeId=04f52e7154bb, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=324f2243128, createdName=1214afeem06暂无昵称, createdTime=Wed Jan 10 11:17:11 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277128, encodeId=80652e7128e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-11 大爰

    学习并分享!!

    0

  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-11 chunjianf

    学习了.谢谢分享

    0

  7. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Wed Jan 10 16:39:03 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277154, encodeId=04f52e7154bb, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=324f2243128, createdName=1214afeem06暂无昵称, createdTime=Wed Jan 10 11:17:11 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277128, encodeId=80652e7128e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 changjiu

    学习一下谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2044034, encodeId=883820440345e, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Mon Apr 30 19:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278796, encodeId=7ce42e87967e, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Thu Jan 11 06:31:57 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277254, encodeId=1fda2e7254ad, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Wed Jan 10 17:35:28 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277232, encodeId=8dd22e7232cf, content=学习了.非常好.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Wed Jan 10 16:39:03 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277154, encodeId=04f52e7154bb, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=324f2243128, createdName=1214afeem06暂无昵称, createdTime=Wed Jan 10 11:17:11 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277128, encodeId=80652e7128e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 cscdliu

    学习了.非常好.谢谢

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2044034, encodeId=883820440345e, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Mon Apr 30 19:12:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278796, encodeId=7ce42e87967e, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Wed Jan 10 16:39:03 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277154, encodeId=04f52e7154bb, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=324f2243128, createdName=1214afeem06暂无昵称, createdTime=Wed Jan 10 11:17:11 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277128, encodeId=80652e7128e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 1214afeem06暂无昵称

    长知识了

    0

  10. 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level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Wed Jan 10 16:39:03 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277154, encodeId=04f52e7154bb, content=长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=324f2243128, createdName=1214afeem06暂无昵称, createdTime=Wed Jan 10 11:17:11 CST 2018, time=2018-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277128, encodeId=80652e7128e3, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jan 10 09:03:51 CST 2018, time=2018-01-10, status=1, ipAttribution=)]
    2018-01-10 明月清辉

    谢谢分享.学习了

    0

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