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Nat Biomed Eng：细胞外囊泡帮助发生心肌梗死的心脏的恢复

2018-05-14 重磅学术期刊 学术经纬

EVs射血分数心脏损伤
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细胞分泌的细胞外囊泡(extracellular vesicles， EVs)能够调控一系列细胞过程，这一特点让它们可能成为治疗疾病的工具。

细胞分泌的细胞外囊泡(extracellular vesicles， EVs)能够调控一系列细胞过程，这一特点让它们可能成为治疗疾病的工具。例如携带细胞特异性微RNAs(microRNAs)的EVs可以帮助心肌梗死发作后的心脏恢复功能，但是通常EVs在体内驻留的时间很短，因此疗效也是短暂的。美国哥伦比亚大学(Columbia University)的研究人员开发出一种人工合成的水凝胶补丁，它能够缓慢释放从诱导多能干细胞分化成的心肌细胞分泌出的EVs。实验结果表明，这种水凝胶补丁在移植到出现心肌梗死的大鼠心脏上之后，能够减少心律不齐的负担，促进射血分数(ejection-fraction)恢复，和降低心肌细胞凋亡。对心肌细胞分泌的EVs的分析表明它们携带着调节心肌细胞特异性功能的心肌特异性微RNA。这项研究表明，持续将从iPSC分化的心肌细胞分泌的EVs运送到心脏中可能帮助治疗心脏损伤，并且帮助加深我们对心脏恢复的理解。

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    2018-08-27 liye789132251

    #Nat#

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    2019-01-22 sunylz

    #Bio#

    0

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    2018-08-18 spoonycyy

    #Eng#

    0

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time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-18 大爰

    学习了谢谢分享!!

    0

  5. 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time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-16 wxl882001

    学习一下

    0

  6. 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time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-16 bnjfx@129.com

    #细胞外囊泡#

    0

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time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-16 charl1234573

    #囊泡#

    0

  8. 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content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 16 08:46:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315422, encodeId=e0aa3154220a, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:45 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-16 ms3994565386320060

    #Med#

    0

  9. 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content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed May 16 08:46:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315422, encodeId=e0aa3154220a, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:45 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-15 changjiu

    学习一下谢谢

    0

  10. 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time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315397, encodeId=33fb31539efd, content=学习一下很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue May 15 19:00:41 CST 2018, time=2018-05-15, status=1, ipAttribution=)]
    2018-05-15 虈亣靌

    学习一下很不错

    0

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