J Periodontol: 拉美裔中牙周炎和氨基转移酶升高的关系

2018-05-30 MedSci MedSci原创

西班牙裔/拉丁裔中非酒精性脂肪肝(NAFLD)患病率高于其他种族/民族,并且西班牙裔/拉丁裔组间有差异。实验动物和人体研究证明牙周炎和NAFLD之间存在关联,而西班牙裔/拉美裔中尚未报道。这项研究检查了牙周炎可能是西班牙裔/拉美裔中NAFLD的一种新的危险因素。

西班牙裔/拉丁裔中非酒精性脂肪肝(NAFLD)患病率高于其他种族/民族,并且西班牙裔/拉丁裔组间有差异。实验动物和人体研究证明牙周炎和NAFLD之间存在关联,而西班牙裔/拉美裔中尚未报道。这项研究检查了牙周炎可能是西班牙裔/拉美裔中NAFLD的一种新的危险因素。

研究纳入西班牙裔拉丁裔社区健康研究的11,914名参与者。牙周炎定义为牙周位点(无,<30%,≥30%)的临床附着水平(CAL)≥3mm或探诊深度(PD)≥4mm。疑似NAFLD的血清转氨酶升高为男性丙氨酸转氨酶水平(ALT)> 40 IU / L或天冬氨酸转氨酶(AST)> 37 IU / L,女性ALT> 31 IU / L或AST> 31 IU / L。用调查 - 逻辑回归模型估计牙周炎与疑似NAFLD之间的患病率比值比(POR)和95%置信区间(CI)。

结果:CAL≥3mm或PD≥4mm的参与者总体年龄标准化百分比分别为53.5%和58.6%,而≥30%的位点分别有16%的CAL≥3 mm或5.72%的PD≥4 mm。疑似NAFLD的总体年龄标化患病率(95%CI)为18.1%(17.1%-19.0%)。在整个队列中观察到PD≥4mm与疑似NAFLD患病率之间存在剂量 - 反应关联,即<30%的受影响受试者POR = 1.19(95%CI:1.03,1.38),而≥30%的受影响者原发性POR = 1.39(95%CI:1.02,1.90)。协变量调整后,这些粗略的估计值被弱化为0。西班牙裔/拉丁裔组没有发现差异。

在西班牙裔/拉丁裔不同群体的研究中,牙周炎与NAFLD之间的关联几乎为零

原始出处:

Akinkugbe AA, et al. Periodontitis and prevalence of elevated aminotransferases in the hispanic community health study/study of latinos. Journal of Periodontology. 2018 May. doi:10.1002/JPER.17-0579

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