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CASC5基因对人类大脑变化发挥重要作用

2016-12-13 科学网 郭爽 科学网 郭爽

CASC5基因人类大脑
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近日，中国科学院昆明动物研究所宿兵实验室在人类大脑进化遗传机制研究中取得新进展，研究成果发表在期刊《人类遗传学》上。人类起源过程中大脑容量的急剧扩增一直是灵长类脑进化研究关注的核心问题。以前的研究主要是比较人类与非人灵长类脑容量的差异及其遗传调控机制，对近期人类进化过程中群体水平脑容量变化的遗传分析少有涉及。昆明动物所宿兵实验室的助理研究员石磊、硕士研究生虎恩志等在近期的研究中发现，脑容量调控基因

近日，中国科学院昆明动物研究所宿兵实验室在人类大脑进化遗传机制研究中取得新进展，研究成果发表在期刊《人类遗传学》上。

人类起源过程中大脑容量的急剧扩增一直是灵长类脑进化研究关注的核心问题。以前的研究主要是比较人类与非人灵长类脑容量的差异及其遗传调控机制，对近期人类进化过程中群体水平脑容量变化的遗传分析少有涉及。

昆明动物所宿兵实验室的助理研究员石磊、硕士研究生虎恩志等在近期的研究中发现，脑容量调控基因CASC5在现代人的起源过程中积累了8个氨基酸突变，这些突变在非人灵长类和古人类（尼安德特人和丹尼索瓦人）中均不存在，是现代人特有的变异位点。其中，2个突变位点在现代人中已经固定下来，而其他6个位点在人群中仍然是多态的。更有意思的是，有4个多态位点在东亚人群中呈现高频率，但在欧洲和非洲人群中频率很低。进一步的分子进化分析表明，CASC5基因在东亚人群中受到达尔文正选择的作用，但在非洲和欧洲群体中没有发现选择信号。

遗传关联分析显示这些东亚人群富集的位点在汉族人群中与大脑灰质体积显著相关，突变型等位基因的携带者具有更大的灰质体积。该研究结果提示，在近期人类大脑进化过程中，CASC5基因对现代人大脑形态结构的变化可能发挥重要作用。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1981840, encodeId=93f9198184025, content=<a href='/topic/show?id=9b6e41310f' target=_blank style='color:#2F92EE;'>#CASC5基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4131, encryptionId=9b6e41310f, topicName=CASC5基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Sun Jun 18 08:56:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938638, encodeId=0fdc1938638b9, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Apr 19 08:56:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023469, encodeId=17e42023469bf, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Jan 15 07:56:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624807, encodeId=353d162480e2a, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Dec 15 05:56:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162720, encodeId=092f162e206b, content=了解了，知道了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 14 11:00:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162491, encodeId=c97f1624919f, content=每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161130/IMG583E843B0477A7780.jpg, createdBy=e4b91988536, createdName=远致静宁, createdTime=Tue Dec 13 15:00:20 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2017-06-18 surilei

    #CASC5基因#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1981840, encodeId=93f9198184025, content=<a href='/topic/show?id=9b6e41310f' target=_blank style='color:#2F92EE;'>#CASC5基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4131, encryptionId=9b6e41310f, topicName=CASC5基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Sun Jun 18 08:56:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938638, encodeId=0fdc1938638b9, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Apr 19 08:56:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023469, encodeId=17e42023469bf, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Jan 15 07:56:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624807, encodeId=353d162480e2a, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Dec 15 05:56:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162720, encodeId=092f162e206b, content=了解了，知道了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 14 11:00:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162491, encodeId=c97f1624919f, content=每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161130/IMG583E843B0477A7780.jpg, createdBy=e4b91988536, createdName=远致静宁, createdTime=Tue Dec 13 15:00:20 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2017-04-19 quxin068

    #ASC#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1981840, encodeId=93f9198184025, content=<a href='/topic/show?id=9b6e41310f' target=_blank style='color:#2F92EE;'>#CASC5基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4131, encryptionId=9b6e41310f, topicName=CASC5基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Sun Jun 18 08:56:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938638, encodeId=0fdc1938638b9, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Apr 19 08:56:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023469, encodeId=17e42023469bf, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Jan 15 07:56:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624807, encodeId=353d162480e2a, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Dec 15 05:56:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162720, encodeId=092f162e206b, content=了解了，知道了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 14 11:00:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162491, encodeId=c97f1624919f, content=每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161130/IMG583E843B0477A7780.jpg, createdBy=e4b91988536, createdName=远致静宁, createdTime=Tue Dec 13 15:00:20 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2017-01-15 jiyangfei

    #重要作用#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1981840, encodeId=93f9198184025, content=<a href='/topic/show?id=9b6e41310f' target=_blank style='color:#2F92EE;'>#CASC5基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4131, encryptionId=9b6e41310f, topicName=CASC5基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Sun Jun 18 08:56:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938638, encodeId=0fdc1938638b9, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Apr 19 08:56:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023469, encodeId=17e42023469bf, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Jan 15 07:56:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624807, encodeId=353d162480e2a, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Dec 15 05:56:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162720, encodeId=092f162e206b, content=了解了，知道了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 14 11:00:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162491, encodeId=c97f1624919f, content=每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161130/IMG583E843B0477A7780.jpg, createdBy=e4b91988536, createdName=远致静宁, createdTime=Tue Dec 13 15:00:20 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-15 yaanren

    #Cas#

    0

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    2016-12-14 186****0580(小山羊）

    了解了，知道了！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1981840, encodeId=93f9198184025, content=<a href='/topic/show?id=9b6e41310f' target=_blank style='color:#2F92EE;'>#CASC5基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4131, encryptionId=9b6e41310f, topicName=CASC5基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e080359, createdName=surilei, createdTime=Sun Jun 18 08:56:00 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1938638, encodeId=0fdc1938638b9, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Wed Apr 19 08:56:00 CST 2017, time=2017-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023469, encodeId=17e42023469bf, content=<a href='/topic/show?id=57ce9605ef6' target=_blank style='color:#2F92EE;'>#重要作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96057, encryptionId=57ce9605ef6, topicName=重要作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8e4c53, createdName=jiyangfei, createdTime=Sun Jan 15 07:56:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624807, encodeId=353d162480e2a, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Dec 15 05:56:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162720, encodeId=092f162e206b, content=了解了，知道了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊）, createdTime=Wed Dec 14 11:00:59 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162491, encodeId=c97f1624919f, content=每天进步一点点, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161130/IMG583E843B0477A7780.jpg, createdBy=e4b91988536, createdName=远致静宁, createdTime=Tue Dec 13 15:00:20 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-13 远致静宁

    每天进步一点点

    0