J Pediatr.:促进棕色脂肪燃烧治疗肥胖

2012-08-09 doctorzark 丁香园

科学家已经找到一种可以用来评估脂肪组织功能的新方法,或许可用来对抗肥胖症。当暴露于“冷刺激”时,对头、颈和肩膀部进行热成像扫描可以发现棕色脂肪(BAT)的区域和位置。BAT可以比体内其他类型的脂肪组织产生更多的热量。“如果你拥有更多的BAT,或你的BAT更活跃,则你很可能会消耗更多热量,因此你体内过多的热量或食物就会更少的沉积到白色脂肪组织中去,”该文章的第一作者,来自英国诺丁汉大学的Michae

科学家已经找到一种可以用来评估脂肪组织功能的新方法,或许可用来对抗肥胖症。当暴露于“冷刺激”时,对头、颈和肩膀部进行热成像扫描可以发现棕色脂肪(BAT)的区域和位置。BAT可以比体内其他类型的脂肪组织产生更多的热量。

“如果你拥有更多的BAT,或你的BAT更活跃,则你很可能会消耗更多热量,因此你体内过多的热量或食物就会更少的沉积到白色脂肪组织中去,”该文章的第一作者,来自英国诺丁汉大学的Michael Symonds说道。他的团队说道,目前用于评估BAT的方法主要有PET、CT和组织扫描,但这些技术不仅昂贵而且带放射性或者是有创的。此外,这些技术仅能用于小规模的人群,而且无法提供BAT的实时功能。

该团队将26个人暴露在标准冷刺激中(即双脚或者一只手浸泡于19-20°C的水中),然后进行热成像扫描,发现温度最高的脂肪组织位于锁骨上方,而且可以指出温度升高的具体部位,该位置与先前通过PET或CT扫描锁定的BAT位置是一致的。该结果已发表在儿科学杂志上。“我们发现在锁骨上方有一小块区域温度持续升高,该区域正是之前通过PET或CT扫描以及组织活检确定的BAT的位置。”研究者写道。

进一步的研究发现,发热区温度升高的程度在儿童(3-8岁)中为0.62℃,青少年(13-18岁)为0.25℃,成人(35-58岁)为0.20℃,三者之间的差异有统计学意义。“在当前儿童肥胖患病率逐渐升高的趋势下,加强青春期前儿童BAT的生热作用也许具有重要的意义,这种非创伤性的技术在与肥胖对抗中起重要作用,”作者说,他们推测那些在低龄阶段就患上肥胖的儿童其特征不仅是白色脂肪细胞的增多,而且伴随BAT的减少。

“未来,可以根据食物是增加还是减少棕色脂肪的产热量将之分类。也就是说,我们将会知道食物是促进还是延缓了我们热量的消耗。”

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    2021-11-09 湘雅科教

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    2012-08-30 feather89
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