J Clin Periodontol：人牙周膜细胞和炎症环境介导维生素 D3 对CD4+T淋巴细胞的多效性

2020-05-31 网络网络

维生素D3和人牙周膜细胞(hPDLCs)均具有免疫抑制特性，但它们对免疫细胞的综合作用还未进行过研究。

维生素D3和人牙周膜细胞(hPDLCs)均具有免疫抑制特性，但它们对免疫细胞的综合作用还未进行过研究。本文分析了维生素D3对hPDLCs 对CD4⁺T淋巴细胞免疫抑制性能的影响。

实验在有无IFN-γ 和1,25 (OH)₂D₃的条件下，植物血凝素在单培养或与hPDLCs 共培养中激活同源CD4⁺T淋巴细胞。5天后，分析CD4⁺T淋巴细胞增殖、CD4⁺CD25⁺FoxP3⁺调节性T淋巴细胞（Tregs）比例以及IL-10、TGF-β1和 IL-17A的产生。

结果发现，在单培养中，1,25 (OH)₂D₃抑制CD4⁺T淋巴细胞增殖，增加了CD4⁺CD25⁺FoxP3⁺Treg的百分比，促进 IL-10和TGF-β1的分泌。在IFN-γ处理的hPDLCs中，1,25 (OH)₂D₃显著促进了CD4⁺T淋巴细胞的增殖，并降低了 CD4⁺CD25⁺FoxP3⁺Treg的百分比。IL-10和IL-17A的表达显著降低了1,25 (OH)₂D₃的水平，而TGF-β1则略有增加。实验通过抑制吲哚胺-2，3-双加氧酶-1、前列腺素内过氧化物合酶和程序性死亡因子配体1，反转了1,25 (OH)₂D₃在共培养中的作用。1,25 (OH)₂D₃还抑制了这些蛋白在hPDLCs中的表达。

因此，维生素 D3 对CD4⁺T淋巴细胞的影响由hPDLCs根据微环境进行修饰。

原文出处：

Christian Behm， Pleiotropic effects of vitamin D3 on CD4+ T lymphocytes mediated by human periodontal ligament cells and inflammatory environment， journal of clinical periodontology， 2020 June， doi： 10.1111/jcpe.13283

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2020-10-23 仁医06

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2021-04-21 124985dbm13(暂无昵称)

#CD4+T淋巴细胞#

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2021-05-17 feather89

#PE#

28 0
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2020-11-04 xqptu

#牙周膜#

45 0
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2020-11-12 xuyu

#CD4+#

42 0
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2020-08-03 qidongfanjian

#CD4#

32 0
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2020-06-02 wetgdt

#淋巴细胞#

32 0
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2020-06-02 医者仁心

#牙周#

33 0
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2020-06-02 zhenjiu129

#T淋巴细胞#

43 0

期刊

J CLIN PERIODONTOL 进入期刊论坛 GetPortalImpactFactorByIdResponse(projectId=1, id=c6e83605, cover=https://img.medsci.cn/images/journal/cover/2021/Uta_202109271315333810.jpg, fullname=JOURNAL OF CLINICAL PERIODONTOLOGY, abbr=J CLIN PERIODONTOL, pyear=1974, frequence=Monthly, articleNumbers=2936, citedSelf2015=17.5, acceptanceRate=30.0, submissionToAcceptance=2.5, averageReviewTime=平均2.5月, reviewFee=null, pageFee=null, publishedRatio=2023年中国人文章占该期刊总数量暂无数据 (2022年为100.00%), issn=0303-6979, greenSci=https://www.greensci.net/search?kw=0303-6979, scijournal=https://www.scijournal.org/impact-factor-of-J-CLIN-PERIODONTOL.shtml, medsciHotlightString=null, medsciHotlightRealtime=6.773, medsciHotlight=3.991, medsciHotlight5year=4.46106, citescore=10.7, hIndex=151, impactFactor=6.7, orgnization=Blackwell Munksgaard, orgnizationUrl=http://onlinelibrary.wiley.com, country=United Kingdom, countryCn=英国, isOa=0, isOaString=否, sciScie=Science Citation Index|Science Citation Index Expanded|Current Contents - Clinical Medicine|Current Contents - Life Sciences, bigclassCas=医学 2区[Top], smallclassCas=医学 2 区, website=https://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X, websiteHits=8095, guideForAuthor=null, guideForAuthorHits=13, submitWebsite=https://mc.manuscriptcentral.com/jcpe, submitWebsiteHits=3546, content=The aim and scope of this Journal is to convey scientific progress in periodontology to those concerned with application of this knowledge for the benefit of the dental health of the community. It will address itself primarily to clinicians general practitioners periodontists as well as to teachers and administrators involved in the organisation of prevention and treatment of periodontal disease. The Journal will publish original contributions of high scientific merit in the field of physiology and pathology of the periodontium diagnosis epidemiology and prevention and therapy of periodontal disease review articles by experts on new developments in basic and applied periodontal science advances in periodontal technique and instrumentation and case reports which illustrate important new information. The language of the Journal is English but all articles will be published with summaries in German and French. The usual selective criteria for acceptance of manuscripts apply for this Journal. The members of the Advisory Board will serve primarily as referees. Publication time will be kept to a minimum in order that new findings can be made generally available in the shortest possible time., totalCites=19675, brief=J CLIN PERIODONTOL杂志医学行业，“<strong><a target="_blank" href="/sci/index.do?smallclass=牙科与口腔外科" >牙科与口腔外科</a></strong>”子行业的优秀级杂志, articleType=绝大部分收录论著，也接收少量其它类型文章, medsciHeat=黑红, medsciComment=J CLIN PERIODONTOL在该细分领域可能是一流杂志，可能是创刊时间短或不是热门学科，整体来说，国内学者关注度仍然不够。对于投稿而言，建议多向"&abbr&"投稿，当然期刊也应该加强品牌宣传。, medsciExplanation=MedSci期刊指数是根据中国科研工作者（含医学临床，基础，生物，化学等学科）对SCI杂志的认知度，熟悉程度，以及投稿的量等众多指标综合评定而成。当然，具体的，您还可以结合“<a href='https://www.medsci.cn/sci/submit.do?id=c6e83605'>投稿经验系统</a>”，进行综合判断，这更是大家的实战经验，值得分享和参考。<br> 注意，上述MedSci期刊指数采用MedSci专利技术，由计算机系统自动计算，并给出建议，存在不准确的可能，仅供您投稿选择杂志时参考。, tags=[ImpactFactorTagDto(id=11384, tagName=牙周, createdHits=2), ImpactFactorTagDto(id=13944, tagName=牙科, createdHits=1), ImpactFactorTagDto(id=198, tagName=口腔, createdHits=1)], citeScoreList=[GetImpactFactorCiteScoreListResponse(year=2016, citescore=4.3), GetImpactFactorCiteScoreListResponse(year=2017, citescore=4.14), GetImpactFactorCiteScoreListResponse(year=2018, citescore=4.73), GetImpactFactorCiteScoreListResponse(year=2019, citescore=7.4), GetImpactFactorCiteScoreListResponse(year=2020, citescore=10.7)], medsciIndexList=[GetImpactFactorMedsciIndexListResponse(year=2020, medsciHotlight=4.716), GetImpactFactorMedsciIndexListResponse(year=2021, medsciHotlight=3.702), GetImpactFactorMedsciIndexListResponse(year=2022, medsciHotlight=10.112), GetImpactFactorMedsciIndexListResponse(year=2023, medsciHotlight=6.271), GetImpactFactorMedsciIndexListResponse(year=2024, medsciHotlight=6.773)], citeScoreGradeList=[GetImpactFactorCiteScoreGradeResponse(smallClass=Dentistry - Periodontics , rank=2/11)], pmcUrl=https://www.ncbi.nlm.nih.gov/nlmcatalog?term=0303-6979[ISSN], pubmedUrl=https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=JOURNAL OF CLINICAL PERIODONTOLOGY[ta], article_number=142, article_number_cn=18, isJournalMember=null, journalType=sci)

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J Clin Periodontol：人牙周膜细胞和炎症环境介导维生素 D3 对CD4+T淋巴细胞的多效性

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