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Sci Rep：扫描声学显微镜和时间分辨荧光光谱用于表征动脉粥样硬化斑块

2018-10-04 MedSci MedSci原创

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动脉粥样硬化斑块是心脏病发作和中风的主要原因，但是目前仍无法明确鉴定斑块。在这里，我们评估扫描声学显微镜（SAM）和时间分辨荧光光谱（TRFS）表征动脉粥样硬化斑块的可行性。我们进行人类颈动脉粥样硬化斑块的双模态显微成像。结果表明，与富含胶原蛋白的区域相比，钙化区域的声阻抗值在统计学上更高。然后我们使用CdTe/CdS量子点通过TRFS对动脉粥样硬化斑块进行成像，显示富含胶原蛋白区域中量子点的荧光

动脉粥样硬化斑块是心脏病发作和中风的主要原因，但是目前仍无法明确鉴定斑块。

在这里，我们评估扫描声学显微镜（SAM）和时间分辨荧光光谱（TRFS）表征动脉粥样硬化斑块的可行性。我们进行人类颈动脉粥样硬化斑块的双模态显微成像。结果表明，与富含胶原蛋白的区域相比，钙化区域的声阻抗值在统计学上更高。然后我们使用CdTe/CdS量子点通过TRFS对动脉粥样硬化斑块进行成像，显示富含胶原蛋白区域中量子点的荧光寿命值与钙化区域中的量子点明显不同。

总之，两种方式都成功地区分钙化区域和斑块内富含胶原蛋白的区域，表明这些技术是确证性的，且可以联合使用以表征日后的动脉粥样硬化斑块。

原始出处：

Bukem Bilen, Belkis Gokbulut, et al., Scanning Acoustic Microscopy and Time-Resolved Fluorescence Spectroscopy for Characterization of Atherosclerotic Plaques. Sci Rep. 2018; 8: 14378.

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    2019-01-28 ms6897892027066920

    #荧光#

    0

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    2019-04-01 huangshifeng

    #粥样硬化#

    0

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    2018-10-07 tulenzi

    #显微镜#

    0

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    2018-10-07 1e1c07bdm01(暂无匿称)

    好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1707786, encodeId=bbb31e0778613, content=<a href='/topic/show?id=bd958e237a6' target=_blank style='color:#2F92EE;'>#荧光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87237, encryptionId=bd958e237a6, topicName=荧光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae2931492970, createdName=ms6897892027066920, createdTime=Mon Jan 28 09:55:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944558, encodeId=f909194455857, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Mon Apr 01 12:55:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893785, encodeId=c7cc1893e8533, content=<a href='/topic/show?id=ab2159e343a' target=_blank style='color:#2F92EE;'>#显微镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59734, encryptionId=ab2159e343a, topicName=显微镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sun Oct 07 07:55:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348316, encodeId=7b1f3483163c, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Oct 07 07:11:56 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330101, encodeId=afe11330101a3, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506662, encodeId=fa401506662fb, content=<a href='/topic/show?id=bf8333308be' target=_blank style='color:#2F92EE;'>#动脉粥样硬化斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33308, encryptionId=bf8333308be, topicName=动脉粥样硬化斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=363d9789626, createdName=lingqf, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347967, encodeId=756f34e96786, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:07 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-06 ms3994565386320060

    #斑块#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1707786, encodeId=bbb31e0778613, content=<a href='/topic/show?id=bd958e237a6' target=_blank style='color:#2F92EE;'>#荧光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87237, encryptionId=bd958e237a6, topicName=荧光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae2931492970, createdName=ms6897892027066920, createdTime=Mon Jan 28 09:55:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944558, encodeId=f909194455857, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Mon Apr 01 12:55:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893785, encodeId=c7cc1893e8533, content=<a href='/topic/show?id=ab2159e343a' target=_blank style='color:#2F92EE;'>#显微镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59734, encryptionId=ab2159e343a, topicName=显微镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sun Oct 07 07:55:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348316, encodeId=7b1f3483163c, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Oct 07 07:11:56 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330101, encodeId=afe11330101a3, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506662, encodeId=fa401506662fb, content=<a href='/topic/show?id=bf8333308be' target=_blank style='color:#2F92EE;'>#动脉粥样硬化斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33308, encryptionId=bf8333308be, topicName=动脉粥样硬化斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=363d9789626, createdName=lingqf, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347967, encodeId=756f34e96786, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:07 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-06 lingqf

    #动脉粥样硬化斑块#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1707786, encodeId=bbb31e0778613, content=<a href='/topic/show?id=bd958e237a6' target=_blank style='color:#2F92EE;'>#荧光#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87237, encryptionId=bd958e237a6, topicName=荧光)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae2931492970, createdName=ms6897892027066920, createdTime=Mon Jan 28 09:55:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944558, encodeId=f909194455857, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Mon Apr 01 12:55:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893785, encodeId=c7cc1893e8533, content=<a href='/topic/show?id=ab2159e343a' target=_blank style='color:#2F92EE;'>#显微镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59734, encryptionId=ab2159e343a, topicName=显微镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Sun Oct 07 07:55:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348316, encodeId=7b1f3483163c, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sun Oct 07 07:11:56 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330101, encodeId=afe11330101a3, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506662, encodeId=fa401506662fb, content=<a href='/topic/show?id=bf8333308be' target=_blank style='color:#2F92EE;'>#动脉粥样硬化斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33308, encryptionId=bf8333308be, topicName=动脉粥样硬化斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=363d9789626, createdName=lingqf, createdTime=Sat Oct 06 13:55:00 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347967, encodeId=756f34e96786, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:07 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-05 明月清辉

    谢谢分享，学习了

    0