JAHA:早发动脉粥样硬化性心血管疾病:发病率、危险因素和性别相关差异的趋势

2019-07-08 xing.T MedSci原创

由此可见,早发性CAD的发生率没有下降,并且在2000年至2016年期间,3种主要心血管危险因素的患病率增加。女性的风险负担和死亡率更差。这些数据对于预防年轻人CAD的策略具有重要意义。

在过去的二十年中,动脉粥样硬化性心血管疾病的发病率有所下降。然而,这些益处可能不会扩展到年轻患者。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。这项工作的目的是评估加拿大不列颠哥伦比亚省年轻患者冠状动脉疾病(CAD)的发病率、风险状况、性别差异和结局的时间趋势。 

研究人员使用省级心脏登记中心确定年轻患者(年龄<50岁的男性,年龄<55岁的女性),在2000年至2016年期间首次发生CAD,1处冠状动脉在血管造影上狭窄≥50%或进行了冠状动脉血运重建术。

共有12519名患者(30%为女性)符合该研究的入选标准。CAD的发病率保持稳定,男性高于女性(46-53 vs. 18-23/10万)。在患者中,92%至少有一种传统的心血管危险因素,67%有多种危险因素。在研究期间,糖尿病、肥胖和高血压的患病率增加,而女性则更高。妇女的急诊手术和血运重建较少。2000年至2007年期间死亡率下降了31%,然后在剩下的9年中保持稳定。与男性相比,年龄<45岁的女性死亡率显著更高。 

由此可见,早发性CAD的发生率没有下降,并且在2000年至2016年期间,3种主要心血管危险因素的患病率增加。女性的风险负担和死亡率更差。这些数据对于预防年轻人CAD的策略具有重要意义。 

原始出处:

Diana N. Vikulova.et al.Premature Atherosclerotic Cardiovascular Disease: Trends in Incidence, Risk Factors, and Sex‐Related Differences, 2000 to 2016.JAHA.2019.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.012178

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22:24:45 CST 2019, time=2019-07-08, status=1, ipAttribution=)]
  5. 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encodeId=6d37149859366, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Jul 10 11:19:00 CST 2019, time=2019-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369314, encodeId=1df5369314b3, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Mon Jul 08 22:24:45 CST 2019, time=2019-07-08, status=1, ipAttribution=)]
    2019-07-10 zhaohui6731
  6. 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  7. 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  8. 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  9. 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    2019-07-08 qingfengqishi5

    学习了,学习了

    0