Eur J Cancer:严重共病影响非小细胞肺癌患者术后生存

2012-08-03 朱金 医学论坛网

  《欧洲癌症杂志》(Eur J Cancer)近期发表的一项研究表明,严重共病影响接受手术切除的非小细胞肺癌(NSCLC)患者的生存。   该研究从丹麦肺癌登记处确定了20461例2005年1月1日至2010年12月和31日确诊为肺癌的患者。在3152例接受切除术的NSCLC患者中,研究根据察尔森共病评分(CCS:0、1、2、3)、东部肿瘤协作组(ECOG)体能状态、肺功能

  《欧洲癌症杂志》(Eur J Cancer)近期发表的一项研究表明,严重共病影响接受手术切除的非小细胞肺癌(NSCLC)患者的生存。

  该研究从丹麦肺癌登记处确定了20461例2005年1月1日至2010年12月和31日确诊为肺癌的患者。在3152例接受切除术的NSCLC患者中,研究根据察尔森共病评分(CCS:0、1、2、3)、东部肿瘤协作组(ECOG)体能状态、肺功能、年龄、性别以及病理学T(pT)和N(pN)分期,使用Cox比例风险模型,计算手术后3个连续时段(0~1个月、1个月至1年和>1年)的死亡风险比;根据CCS,用Kaplan-Meier分析来描述肿瘤特定分期的生存状况。

  结果显示,贯穿整个随访的3个时段,严重共病(CCS 3+)与显著较高的死亡率呈独立相关性。在有严重共病的患者中,特定分期的5年生存率显著低于无共病的患者。

  相关链接:Lüchtenborg M, Jakobsen E, Krasnik M, Linklater KM, Mellemgaard A, Møller H.The effect of comorbidity on stage-specific survival in resected non-small cell lung cancer patients.Eur J Cancer. 2012 Jul 12
 



    

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