CGH:无症状和轻度 COVID-19 患者的粪便样本中也可以检测到 SARS-CoV-2病毒

2021-06-30 MedSci原创 MedSci原创

众所周知,大多数 COVID-19 患者会发烧并伴有呼吸道症状,人与人之间的传播发生在密切接触者之间,而且病毒主要通过呼吸道飞沫和直接接触传播。

      众所周知,大多数 COVID-19 患者会发烧并伴有呼吸道症状,人与人之间的传播发生在密切接触者之间,而且病毒主要通过呼吸道飞沫和直接接触传播。新型冠状病毒引起的疾病通常伴有胃肠道(GI)表现,本项研究旨在探究无症状或轻度 COVID-19 患者的胃肠道症状和病毒在粪便中的存活情况。

 

      研究人员从 2020年4月4日至4月确诊的46名无症状或轻度 COVID-19(无发热和肺炎)患者(中位年龄,26 岁;46% 男性)和存在呼吸道感染 的SARS-CoV-2 阳性的患者中收集了样本数据,在韩国。呼吸道标本包括上呼吸道标本(鼻咽和口咽拭子)和下呼吸道标本(痰),每周采集两次。从 COVID-19 诊断到开始收集粪便样本之间的中位间隔为 37 天;同时收集了46名患者的 213 份粪便标本。我们使用实时逆转录聚合酶链反应检测呼吸道和粪便样本中的 SARS-CoV-2的表达情况。

 

      46 名患者中有 16 名患者 (35%) 存在胃肠道表现;腹泻是最常见的(15%),其次是腹痛(11%)、消化不良(11%)和恶心(2%)。在 2 名没有胃肠道症状的患者 (4%) 的粪便中检测到病毒RNA表达。粪便样本中检测到病毒的患者从隔离时间到粪便收集时间的平均周期阈值往往低于粪便样本中未检测到病毒的患者(第一周为 29.91 VS 33.67,第五周为 29.47 VS 35.71)。病毒可以在粪便中一直持续存活 50 天。

图:粪便中新冠病毒的存活量差异

      本项研究发现胃肠道可能是 SARS-CoV-2 的传播途径之一,即使是无症状或轻度疾病的患者粪便中也可能存在病毒。

 

 

原始出处 :

Soo-kyung Park. Et al. Detection of SARS-CoV-2 in Fecal Samples From Patients With Asymptomatic and Mild COVID-19 in Korea. Clinical Gastroenterology Hepatology. 2021.

 

 

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    2021-08-22 zhzhxiang
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    2022-05-03 chendoc242
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    2022-01-30 hukaixun
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    2021-07-02 小刀医生
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    2021-07-02 Homburg
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    2021-07-01 随风1991

    这个事不是早就说过吗?

    0

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