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Microb Pathog：丁子香酚和丁香叶精油可有效对抗牙周致病菌

2018-05-09 MedSci MedSci原创

丁香叶精油丁子香酚牙龈卟啉单胞菌
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本研究旨在探究丁香叶精油（CLEO）及丁子香酚对口腔厌氧菌牙龈卟啉单胞菌的抑菌作用及机制。结果表明，丁香酚在CLEO中含量为90.84％，在31.25μM浓度时对牙龈卟啉单胞菌具有抗菌活性。扫描电子显微镜（SEM）观察发现，丁子香酚可引起细胞收缩和裂解。大分子的释放和荧光染料的摄取表明，丁子香酚科室细胞膜透化并且不可逆地破坏血浆膜完整性的能力来发挥抗菌活性。此外，丁子香酚抑制生物膜形成并降低不同浓

本研究旨在探究丁香叶精油（CLEO）及丁子香酚对口腔厌氧菌牙龈卟啉单胞菌的抑菌作用及机制。

结果表明，丁香酚在CLEO中含量为90.84％，在31.25μM浓度时对牙龈卟啉单胞菌具有抗菌活性。扫描电子显微镜（SEM）观察发现，丁子香酚可引起细胞收缩和裂解。大分子的释放和荧光染料的摄取表明，丁子香酚科室细胞膜透化并且不可逆地破坏血浆膜完整性的能力来发挥抗菌活性。

此外，丁子香酚抑制生物膜形成并降低不同浓度的牙龈卟啉单胞菌的预形成生物膜。与生物膜有关的毒力因子基因（fimA，hagA，hagB，rgpA，rgpB，kgp）的下调解释了丁香酚在初始阶段抑制生物膜形成。

综上所述，该研究结果表明，丁子香酚和CLEO或可成为食品和个人保健产品中的潜在添加剂，作为预防牙周炎的方法。

原始出处：

Zhang Y, Wang Y, et al., Antibacterial and antibiofilm activities of eugenol from essential oil of Syzygium aromaticum (L.) Merr. & L. M. Perry (clove) leaf against periodontal pathogen Porphyromonas gingivalis. Microb Pathog. 2017 Dec;113:396-402. doi: 10.1016/j.micpath.2017.10.054. Epub 2017 Oct 31.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2005147, encodeId=cf81200514e12, content=<a href='/topic/show?id=2e1e6e542cb' target=_blank style='color:#2F92EE;'>#牙周致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67542, encryptionId=2e1e6e542cb, topicName=牙周致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Thu Aug 16 05:15:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857642, encodeId=cc97185e642eb, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Jun 10 08:15:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738203, encodeId=076d1e38203e2, content=<a href='/topic/show?id=f59a1949548' target=_blank style='color:#2F92EE;'>#丁香#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19495, encryptionId=f59a1949548, topicName=丁香)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef7534383838, createdName=ms3323097325231039, createdTime=Mon Dec 03 18:15:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084394, encodeId=7b042084394dc, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Dec 06 12:15:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450874, encodeId=03ab14508e45e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584584, encodeId=2102158458439, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626209, encodeId=14da162620951, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-08-16 bbwuyu_003

    #牙周致病菌#

    0

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    2018-06-10 jiafufeng@yaho

    #CRO#

    0

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    2018-12-03 ms3323097325231039

    #丁香#

    0

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    2018-12-06 xjy02

    #Micro#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2005147, encodeId=cf81200514e12, content=<a href='/topic/show?id=2e1e6e542cb' target=_blank style='color:#2F92EE;'>#牙周致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67542, encryptionId=2e1e6e542cb, topicName=牙周致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Thu Aug 16 05:15:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857642, encodeId=cc97185e642eb, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Jun 10 08:15:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738203, encodeId=076d1e38203e2, content=<a href='/topic/show?id=f59a1949548' target=_blank style='color:#2F92EE;'>#丁香#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19495, encryptionId=f59a1949548, topicName=丁香)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef7534383838, createdName=ms3323097325231039, createdTime=Mon Dec 03 18:15:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084394, encodeId=7b042084394dc, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Dec 06 12:15:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450874, encodeId=03ab14508e45e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584584, encodeId=2102158458439, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626209, encodeId=14da162620951, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-11 liuyong2982

    #牙周#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2005147, encodeId=cf81200514e12, content=<a href='/topic/show?id=2e1e6e542cb' target=_blank style='color:#2F92EE;'>#牙周致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67542, encryptionId=2e1e6e542cb, topicName=牙周致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Thu Aug 16 05:15:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857642, encodeId=cc97185e642eb, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Jun 10 08:15:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738203, encodeId=076d1e38203e2, content=<a href='/topic/show?id=f59a1949548' target=_blank style='color:#2F92EE;'>#丁香#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19495, encryptionId=f59a1949548, topicName=丁香)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef7534383838, createdName=ms3323097325231039, createdTime=Mon Dec 03 18:15:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084394, encodeId=7b042084394dc, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Dec 06 12:15:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450874, encodeId=03ab14508e45e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584584, encodeId=2102158458439, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626209, encodeId=14da162620951, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-11 ms4657536712156177

    #精油#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2005147, encodeId=cf81200514e12, content=<a href='/topic/show?id=2e1e6e542cb' target=_blank style='color:#2F92EE;'>#牙周致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67542, encryptionId=2e1e6e542cb, topicName=牙周致病菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60b4474, createdName=bbwuyu_003, createdTime=Thu Aug 16 05:15:00 CST 2018, time=2018-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857642, encodeId=cc97185e642eb, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Jun 10 08:15:00 CST 2018, time=2018-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1738203, encodeId=076d1e38203e2, content=<a href='/topic/show?id=f59a1949548' target=_blank style='color:#2F92EE;'>#丁香#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19495, encryptionId=f59a1949548, topicName=丁香)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ef7534383838, createdName=ms3323097325231039, createdTime=Mon Dec 03 18:15:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084394, encodeId=7b042084394dc, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Thu Dec 06 12:15:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450874, encodeId=03ab14508e45e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584584, encodeId=2102158458439, content=<a href='/topic/show?id=94d0e645660' target=_blank style='color:#2F92EE;'>#精油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76456, encryptionId=94d0e645660, topicName=精油)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=537517051731, createdName=ms4657536712156177, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626209, encodeId=14da162620951, content=<a href='/topic/show?id=c11d864884d' target=_blank style='color:#2F92EE;'>#致病菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86488, encryptionId=c11d864884d, topicName=致病菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d320995014, createdName=cooco, createdTime=Fri May 11 04:15:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-11 cooco

    #致病菌#

    0