Cell Metab:骨细胞堪称 全身健康的卫士

2013-10-23 佚名 新华社

日本研究人员发现,形成骨骼的骨细胞对于维持身体健康也发挥着重要作用,不仅能够提高免疫力,还能适度保持整个身体的脂肪量。 日本神户大学和北海道大学的研究人员在新一期美国《细胞—代谢》杂志网络版上报告说,实验鼠在全身骨细胞都受到损伤的3周后,与正常实验鼠相比,病鼠血液中免疫细胞的数量减少了,其中B淋巴细胞减少约75%,T淋巴细胞减少约60%。骨细胞受损的实验鼠的脂肪也减少

日本研究人员发现,形成骨骼的骨细胞对于维持身体健康也发挥着重要作用,不仅能够提高免疫力,还能适度保持整个身体的脂肪量。

日本神户大学和北海道大学的研究人员在新一期美国《细胞—代谢》杂志网络版上报告说,实验鼠在全身骨细胞都受到损伤的3周后,与正常实验鼠相比,病鼠血液中免疫细胞的数量减少了,其中B淋巴细胞减少约75%,T淋巴细胞减少约60%。骨细胞受损的实验鼠的脂肪也减少了,体重下降了约40%。

研究人员进一步发现,实验鼠的骨细胞受损后,体内制造B淋巴细胞的骨髓和制造T淋巴细胞的胸腺细胞都减少了。

参与研究的北海道大学助教佐藤真理说:“这说明骨细胞会对淋巴细胞的发育环境产生影响。骨细胞具有保障全身健康的作用。”

研究人员认为,如果能够通过运动和药物刺激骨骼,增强其功能,就有望对因老化而衰弱的骨骼以及由此引发的免疫功能不全或高脂血症进行治疗。这一发现还能解释,为何卧床不起的人和在无重力条件下工作的宇航员的免疫力会变差。

原文出处:

Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y.Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism.Cell Metab. 2013 Oct 15. pii: S1550-4131(13)00383-5. doi: 10.1016/j.cmet.2013.09.014. 

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    2014-08-20 维他命
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    2014-08-31 一闲
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    2014-06-03 guojianrong
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