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Sci Rep：通过损伤细胞外囊泡REG3β可改变肿瘤细胞的功能

2017-08-07 MedSci MedSci原创

Reg3β细胞外囊泡胰腺癌
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细胞外囊泡（EVs），包括外泌体和微泡，均是含有蛋白质和核酸可作为细胞间信使的纳米级囊泡。EVs不仅在各种生理过程中起着重要作用，在炎症或癌症等病理情况下也起着重要作用。该研究表明，在胰腺导管腺癌（PDAC）的情况下，肿瘤周围正常胰腺组织可释放的REG3β——存在EVs表面连接糖蛋白的一种凝集素，从而干扰靶细胞的摄入和内化。在体外，由于REG3β的存在可扰乱EVs介导的通路，防止EV介导巨噬细胞的

细胞外囊泡（EVs），包括外泌体和微泡，均是含有蛋白质和核酸可作为细胞间信使的纳米级囊泡。EVs不仅在各种生理过程中起着重要作用，在炎症或癌症等病理情况下也起着重要作用。

该研究表明，在胰腺导管腺癌（PDAC）的情况下，肿瘤周围正常胰腺组织可释放的REG3β——存在EVs表面连接糖蛋白的一种凝集素，从而干扰靶细胞的摄入和内化。在体外，由于REG3β的存在可扰乱EVs介导的通路，防止EV介导巨噬细胞的表型转换，抑制癌细胞的迁移，并可反转EVs促进的代谢改变。在体内，肿瘤细胞摄取REG3β明显受损。此外，胰腺癌患者血液中循环REG3β+ EVs水平的增加。

总之，该研究结果强调肿瘤细胞周围健康胰腺组织释放的凝集素在调节EV介导的PDAC不同细胞类型之间关系的作用。

原始出处：

Laia Bonjoch, Meritxell Gironella, et al., REG3β modifies cell tumor function by impairing extracellular vesicle uptake. Sci Rep. 2017; 7: 3143. Published online 2017 Jun 9. doi: 10.1038/s41598-017-03244-4.


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    2017-08-09 hmwwww

    #肿瘤细胞#

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    2017-08-09 ms3046638856685384

    #损伤#

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    2017-08-09 bnjfx@129.com

    #细胞外囊泡#

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    2017-08-09 charl1234573

    #囊泡#

    0

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    2017-08-07 半夏微凉

    学习了谢谢分享

    0

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SCI REP：REG3β通过损害细胞外囊泡摄取来改变细胞肿瘤功能

细胞外囊泡（EVs），包括外来体和微泡，是含有蛋白质和核酸的纳米级膜囊泡，其作为细胞间信使发挥功能。它们在各种生理过程甚至病理状况，如炎症或癌症中起重要作用。在项研究中，我们发现，在胰腺导管腺癌（PDAC）中，肿瘤周围的健康胰腺组织释放REG3β，这是一种与EVs表面存在的糖蛋白结合的凝集素，因此这些细胞可以干扰其被靶细胞吸收和内化。

Nat Med：Reg3β依赖性巨噬细胞促进心肌愈合

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