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Acta Biomater：研究揭示Setd2与锶诱导的骨再生有关

2018-01-23 MedSci MedSci原创

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雷尼酸锶可用作骨质疏松症的预防性治疗，Sr离子的释放对于预防破骨细胞活化和促进成骨细胞分化具有直接作用。本研究既往制备并表征了一种多孔的Sr-中孔生物活性玻璃（Sr-MBG）支架，与单独的MBG相比，Sr-MBG可显著增强新骨形成的能力。本研究旨在通过在体内组织样品上利用RNA-seq来阐明Sr的骨诱导特性以研究负责Sr诱导的新骨形成的潜在靶基因。结果表明，与单独的MBG组相比，Sr-MBG组Se

雷尼酸锶可用作骨质疏松症的预防性治疗，Sr离子的释放对于预防破骨细胞活化和促进成骨细胞分化具有直接作用。本研究既往制备并表征了一种多孔的Sr-中孔生物活性玻璃（Sr-MBG）支架，与单独的MBG相比，Sr-MBG可显著增强新骨形成的能力。本研究旨在通过在体内组织样品上利用RNA-seq来阐明Sr的骨诱导特性以研究负责Sr诱导的新骨形成的潜在靶基因。

结果表明，与单独的MBG组相比，Sr-MBG组Setd2的表达增加。免疫荧光染色进一步证实在用Sr-MBG支架处理的骨缺损中，Setd2和H3K36me3 定位在Runx2阳性的细胞中。Sr所刺激的MG63中可检测到特异性的MAPK通路的激活。为了验证在SrCl 2的存在下Setd2在骨形成中的作用，在有/无SrCl 2刺激的MG63中敲低和过表达Setd2。结果显示，Setd2在成骨细胞分化过程中起着积极的作用，而SrCl2增强了成骨细胞的分化。此外，研究人员发现Setd2可调节ERK的激活，在成骨细胞分化过程中具有积极的作用。

基于这些发现，认为Setd2在成骨细胞分化中具有积极的作用。作为一种组蛋白甲基化酶，Setd2或可成为骨质疏松症新的表观遗传学治疗靶点。

原始出处：

Jia X, Long Q, et al., Setd2 is associated with strontium-induced bone regeneration. Acta Biomater. 2017 Apr 15;53:495-505. doi: 10.1016/j.actbio.2017.02.025. Epub 2017 Feb 20.

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    2018-11-25 windight

    #CTA#

    0

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    2018-12-12 sunylz

    #Bio#

    0

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    2018-04-27 zutt

    #SETD2#

    0

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    2018-01-26 1217549fm29暂无昵称

    henhao

    0

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    2018-01-25 villahu

    #锶#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1849581, encodeId=1f1e1849581c2, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Nov 25 17:59:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917895, encodeId=8b3e191e895ba, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 12 09:59:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668739, encodeId=5e901668e3952, content=<a href='/topic/show?id=65b7161e6d6' target=_blank style='color:#2F92EE;'>#SETD2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16176, encryptionId=65b7161e6d6, topicName=SETD2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a2826396833, createdName=zutt, createdTime=Fri Apr 27 13:59:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282301, encodeId=1f9a2823012e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Fri Jan 26 21:54:30 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460742, encodeId=53e41460e42a3, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Thu Jan 25 11:59:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472104, encodeId=e7e114e2104d1, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 11:59:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281584, encodeId=c560281584ee, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Jan 24 13:06:35 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-25 智慧医人

    #骨再生#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1849581, encodeId=1f1e1849581c2, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Nov 25 17:59:00 CST 2018, time=2018-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917895, encodeId=8b3e191e895ba, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=14, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Wed Dec 12 09:59:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668739, encodeId=5e901668e3952, content=<a href='/topic/show?id=65b7161e6d6' target=_blank style='color:#2F92EE;'>#SETD2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16176, encryptionId=65b7161e6d6, topicName=SETD2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a2826396833, createdName=zutt, createdTime=Fri Apr 27 13:59:00 CST 2018, time=2018-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282301, encodeId=1f9a2823012e, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9d2256316, createdName=1217549fm29暂无昵称, createdTime=Fri Jan 26 21:54:30 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460742, encodeId=53e41460e42a3, content=<a href='/topic/show?id=668b96e72d9' target=_blank style='color:#2F92EE;'>#锶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96772, encryptionId=668b96e72d9, topicName=锶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a21b6366000, createdName=villahu, createdTime=Thu Jan 25 11:59:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472104, encodeId=e7e114e2104d1, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智慧医人, createdTime=Thu Jan 25 11:59:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281584, encodeId=c560281584ee, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Jan 24 13:06:35 CST 2018, time=2018-01-24, status=1, ipAttribution=)]
    2018-01-24 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0