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Radiology：抗病毒治疗在延缓慢性乙肝肝硬化进展的作用有多大呢？

2018-04-24 shaosai MedSci原创

乙肝抗病毒肝硬化
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本研究旨在探究声学辐射压力脉冲（ARFI）超声（US）成像在慢性乙肝患者的临床应用及纵向研究的价值，并将研究结果发表在Radiology上。

本研究旨在探究声学辐射压力脉冲（ARFI）超声（US）成像在慢性乙肝患者的临床应用及纵向研究的价值，并将研究结果发表在Radiology上。

本研究纳入了慢性乙肝并行多次ARFI检查的患者。收集患者临床病史及非侵入性肝硬化评价测试(ARFI， FIB-4和FibroScan)。比较抗病毒乙肝患者与未抗病毒乙肝患者ARFI指标。利用线性混合效应模型比较纵向多次重复测量数据。

本研究共纳入了59例行多次ARFI检查的患者。ARFI值与FIB-4（相关系数为0.55， P < .001）和FibroScan（相关系数为0.69， P < .001）具有相关性。共有314例患者在3年的随访中进行了5次以上的ARFI检查。在未抗病毒治疗患者组，ARFI值并未发生变化(n = 189， 从1.11到1.11 m/sec， 时间趋势P = .911)。然而，在治疗组，ARFI值显着下降(n = 125，从1.63到.37 m/sec， 时间趋势P < .001)，有肝硬化的治疗组ARFI值 (n = 51，从2.15到1.75 m/sec，时间趋势P < .001)和无肝硬化的治疗组(n = 74，从1.27到1.11 m/sec，时间趋势P < .001)均有下降。

本研究表明，ARFI US成像是临床上评价肝硬化的一种重要的非侵入性方法，可对慢性乙肝患者进行多次连续检查。在纵向随访中，抗病毒治疗能够有效地减轻肝硬化程度。

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    2018-05-01 yfjms

    学习

    0

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    2018-04-28 秀红

    学习了

    0

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    2018-04-25 yahu

    #抗病毒#

    0

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    2018-04-25 dangious

    #抗病毒治疗#

    0

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    2018-04-25 yfjms

    学习

    0

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    2018-04-25 121832a9m88暂无昵称

    学习了

    0

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    2018-04-24 明月清辉

    谢谢分享.学习了

    0

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    2018-04-24 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-04-24 龙胆草

    学习谢谢分享

    0

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    2018-04-24 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

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