Carbohydr Polym：3D打印的PHBV/硫酸钙半水合物支架和壳聚糖水凝胶可有效促进成骨

2018-10-06 MedSci MedSci原创

本研究中，研究人员使用熔融沉积建模（FDM）技术开发了3D打印的聚（3-羟基丁酸酯-共-3-羟基戊酸酯）/硫酸钙半水合物（PHBV/CaSH）支架，然后使用壳聚糖（CS）乙酸溶液涂覆支架。干燥和中和后，支架的表面上形成CS水凝胶。得到的PHBV/CaSH/CS支架可以促进大鼠骨髓基质细胞（rBMSCs）的粘附和增殖，并通过与PHBV和PHBV/CaSH支架相比上调成骨基因的表达水平来增强

本研究中，研究人员使用熔融沉积建模（FDM）技术开发了3D打印的聚（3-羟基丁酸酯-共-3-羟基戊酸酯）/硫酸钙半水合物（PHBV/CaSH）支架，然后使用壳聚糖（CS）乙酸溶液涂覆支架。

干燥和中和后，支架的表面上形成CS水凝胶。得到的PHBV/CaSH/CS支架可以促进大鼠骨髓基质细胞（rBMSCs）的粘附和增殖，并通过与PHBV和PHBV/CaSH支架相比上调成骨基因的表达水平来增强rBMSCs的成骨。体内研究进一步证明PHBV/CaSH /CS支架可有效促进新骨形成。

因此，整合3D打印的PHBV/CaSH支架和CS hrydogel可有效促进骨修复，显示出骨缺损修复的全部潜力。

原始出处：

Ye X, Li L, et al., Integrating 3D-printed PHBV/Calcium sulfate hemihydrate scaffold and chitosan hydrogel for enhanced osteogenic property. Carbohydr Polym. 2018 Dec 15;202:106-114. doi: 10.1016/j.carbpol.2018.08.117. Epub 2018 Aug 28.

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2019-06-03 klivis

#HBV#

38 0
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2018-10-08 tastas

#水凝胶#

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2018-10-08 ms9833124466084992

#3D#

27 0
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2018-10-08 zhaojie88

#成骨#

28 0
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2018-10-08 lishizhe

#凝胶#

36 0
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2018-10-08 dlwang_26703132

#壳聚糖#

31 0
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2018-10-07 一天没事干

很好的学习机会

40 0
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2018-10-06 医者仁心5538

学习了

46 0

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