Neurology:中风后早期脑老化MRI标记

2017-06-10 zhangfan MedSci原创

在缺血性脑卒中血管危险因素之前,大脑结构很可能已受到损害,主要表现为海马体积和总脑体积减小和脑白质高信号体积增加

近日研究人员研究了缺血性脑卒中血管危险因素和脑老化的MRI标记之间的关系。

研究招募了81名患者,平均年龄67.5岁,其中66人为首次中风,15人为复发中风,患者在发病6周内进行3T-MRI扫描,研究同时招募了40名年龄相仿对照组。通过多元回归分析研究各组成员与脑老化的MRI标记(皮质厚度、全脑体积、脑白质[WMH]高信号体积,海马体积)归一化颅内容积以及血管危险影响因素之间的关系。

研究表明,首次中风患者相对于健康对照海马体积小、WMH体积增大。中风复发患者相比于其余两组海马体积减小。对年龄、性别、教育程度以及中风患者梗死体积后进行调整后相关性仍然显著。首次卒中患者的总脑体积相对于对照组无明显减小,但对心房颤动后调整后,相关性显著增加。皮质厚度和脑体积与卒中类型、梗死体积或病因无关。

研究表明在缺血性脑卒中血管危险因素之前,大脑结构很可能已受到损害,主要表现为海马体积和总脑体积减小和脑白质高信号体积增加。

原始出处:


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    2017-12-24 yinhl1978
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    2017-06-12 虈亣靌

    谢谢分享,很有用

    0

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    2017-06-10 七九九八

    继续努力

    0

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    2017-06-10 1e131038m59(暂无匿称)

    学习了,谢谢分享。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999974, encodeId=c7af19999e4e0, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sun Dec 24 05:34:00 CST 2017, time=2017-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209818, encodeId=59962098182f, content=谢谢分享,很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Jun 12 12:21:27 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388005, encodeId=2a36138800520, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sun Jun 11 23:34:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208943, encodeId=670e2089435e, content=继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCcmyvDOwDu2ZpuYyovmsD12IBHmUCwr5bZqNic2p50ogCxUAIj4YqJ3PsGwoXOhJPQAvicmu6RqOww/0, createdBy=a0bf1958339, createdName=七九九八, createdTime=Sat Jun 10 10:56:55 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208929, encodeId=1e5120892914, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e7f41959343, createdName=1e131038m59(暂无匿称), createdTime=Sat Jun 10 09:11:26 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208921, encodeId=033d20892142, content=脑血管疾病始终是要攻克的任务。, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Jun 10 09:01:11 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-10 惠映实验室

    脑血管疾病始终是要攻克的任务。

    0

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