Ebiomedicne：中国科学家开发非小细胞肺癌新诊断工具

2015-08-19 佚名生物谷

由于缺少非小细胞肺癌(NSCLC)的血液检测方法，也没有明显的临床症状，早期阶段的非小细胞肺癌非常难于检测。在一项发表在国际学术期刊Ebiomedicine的最新文章中，来自南京大学的研究人员在血清中发现了5种microRNA，或可作为非小细胞肺癌的诊断标记为该疾病的早期诊断带来曙光。 MiRNA是一类小的单链非编码RNA，在许多疾病中作为关键调控因子发挥作用，并且根据不同miRNA的表

由于缺少非小细胞肺癌(NSCLC)的血液检测方法，也没有明显的临床症状，早期阶段的非小细胞肺癌非常难于检测。在一项发表在国际学术期刊Ebiomedicine的最新文章中，来自南京大学的研究人员在血清中发现了5种microRNA，或可作为非小细胞肺癌的诊断标记为该疾病的早期诊断带来曙光。

MiRNA是一类小的单链非编码RNA，在许多疾病中作为关键调控因子发挥作用，并且根据不同miRNA的表达情况还可以诊断多种类型的癌症。在该研究小组之前的研究工作中，他们已经发现人的体液如血清中包含许多稳定的miRNA，因此血清中的miRNA可能在一些癌症的检测中作为生物标记物发挥重大潜能。

在这项最新研究中，研究人员招募了来自中国和美国的438名参与者，其中包括221名NSCLC病人，161名对照和56名良性结节患者。他们利用高通量的Taqman低密度miRNA芯片技术结合qRT-PCR在来自三个不同队列的中国NSCLC病人样本中成功发现了5种血清miRNA在NSCLC病人体内显著增加，随后在一个美国队列中进行了验证，对这5种miRNA能否用作不同种族NSCLC的可靠诊断标记进行了评估。

结果表明这一组合在对NSCLC和对照人群的区分上具有很高的准确性，并且无论是对中国人还是美国人效果都相同。更为重要的是，这种miRNA诊断组合还能够正确预测I-II期肿瘤，并可以对美国队列中的NSCLC和良性结节病人进行区分。

总的来说，这项研究发现的5种血清miRNA能够准确诊断NSCLC，并且对不同种族的人群具有相同效果，这对于NSCLC的早期诊断手段开发具有重要意义。

原文出处：

Cheng Wanga, Meng DingaA. et al. Five-miRNA Panel Identified from a Multicentric Case-control Study Serves as a Novel Diagnostic Tool for Ethnically Diverse Non-small-cell Lung Cancer Patients.Ebiomedicine.2015

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2016-05-01 surilei

#诊断工具#

31 0
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2016-01-12 rgjl

#新诊断#

32 0
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2016-05-22 jeanqiuqiu

#DIC#

27 0
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2016-01-16 medsic

嗯，

95 0
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2016-01-16 medsic

嗯，

62 0
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2016-01-16 medsic

好消息！

138 0
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2016-01-16 medsic

好消息！

93 0
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2016-01-16 medsic

不错～～

101 0
[GetPortalCommentsPageByObjectIdResponse(id=1723626, encodeId=23141e23626e8, content=<a href='/topic/show?id=7b08915917b' target=_blank style='color:#2F92EE;'>#诊断工具#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91591, encryptionId=7b08915917b, topicName=诊断工具)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c37033510464, createdName=surilei, createdTime=Sun May 01 11:11:00 CST 2016, time=2016-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915257, encodeId=edaf191525e67, content=<a href='/topic/show?id=e381586e94d' target=_blank style='color:#2F92EE;'>#新诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58679, encryptionId=e381586e94d, topicName=新诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b48400, createdName=rgjl, createdTime=Tue Jan 12 20:11:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858620, encodeId=b6f5185862048, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Sun May 22 16:11:00 CST 2016, time=2016-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57750, encodeId=b19b5e7500f, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57751, encodeId=54805e7515e, content=嗯，, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57752, encodeId=0cb35e752ed, content=好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57753, encodeId=e43c5e753c1, content=好消息！, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57754, encodeId=a8f45e75413, content=不错～～, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57755, encodeId=f0355e755b6, content=不错～～, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32ba1611217, createdName=medsic, createdTime=Sat Jan 16 00:31:00 CST 2016, time=2016-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997071, encodeId=fcde199e07157, content=<a href='/topic/show?id=9221645e6f' target=_blank style='color:#2F92EE;'>#EBI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6457, encryptionId=9221645e6f, topicName=EBI)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Mon Oct 26 22:11:00 CST 2015, time=2015-10-26, status=1, ipAttribution=)]
2016-01-16 medsic

不错～～

141 0
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2015-10-26 linagood

#EBI#

28 0

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