Hypertension:体位性低血压与痴呆症发生风险之间的相关性分析!

2017-05-31 xing.T MedSci原创

总之,OH与痴呆之间存在相关性。考虑到OH是一种很常见的疾病,并且也很容易进行测量,OH测量可以帮助确定痴呆风险较高的受试者。此外,减少OH可能是防止向痴呆症转化的一个步骤。

一些研究表明体位性低血压(OH)和痴呆发生之间存在潜在的联系,但没有确凿的证据。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在通过一个老年人队列评估OH和老年痴呆症之间的相关性。

要做到这一点,研究人员将三个城市研究的7425名受试者测量了其基线卧位和站立位血压。研究人员将这些受试者随访了12年,在调整潜在的混杂因素后,采用Cox比例风险模型根据OH状态来估计痴呆发生的风险。同时,使用所谓的疾病死亡模型进行敏感性分析,一种特别的考虑到死亡竞争风险的统计方法。

研究人员发现OH发生频率为13%左右,在随访期间诊断为痴呆的患者有760例。研究人员观察到基础OH与随访期间痴呆症的发生之间存在显著的相关性,至少可以观察到风险增加25%,无论OH阈值和使用的统计方法。

总之,OH与痴呆之间存在相关性。考虑到OH是一种很常见的疾病,并且也很容易进行测量,OH测量可以帮助确定痴呆风险较高的受试者。此外,减少OH可能是防止向痴呆症转化的一个步骤。

原始出处:

Antoine Cremer,et al. Orthostatic Hypotension and Risk of Incident Dementia
Results From a 12-Year Follow-Up of the Three-City Study Cohort
.Hypertension. 2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09048

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    2017-10-04 Boyinsh
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    2017-09-04 feather89
  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 31 09:33:13 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2038673, encodeId=813f20386e337, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Aug 21 15:21:00 CST 2017, time=2017-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837250, encodeId=8f27183e25047, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Fri Dec 15 11:21:00 CST 2017, time=2017-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836149, encodeId=40cc183614992, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Oct 04 10:21:00 CST 2017, time=2017-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726445, encodeId=72c11e2644544, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, 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encodeId=bd3320506516, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Jun 01 06:17:58 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204929, encodeId=fe6420492934, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Wed May 31 21:42:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204759, encodeId=ceca204e59d8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 31 09:33:13 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-06-01 meiliwuxian

    学习了

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 31 09:33:13 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-05-31 海棠胜雪

    学习了

    0

  10. 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encodeId=bd3320506516, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=445f1740270, createdName=meiliwuxian, createdTime=Thu Jun 01 06:17:58 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204929, encodeId=fe6420492934, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Wed May 31 21:42:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204759, encodeId=ceca204e59d8, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed May 31 09:33:13 CST 2017, time=2017-05-31, status=1, ipAttribution=)]
    2017-05-31 明月清辉

    谢谢分享,学习了

    0