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Arthritis & Rheumatology: 信号素：从类风湿性关节炎的血管生成到炎症发生

2021-09-27 彼岸河边草 MedSci原创

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信号素包括一组结构相似的分子，特征是存在约500个氨基酸的Sema结构域，广泛表达于免疫细胞中，并在各种免疫应答中发挥作用。该文章目的是研究信号素在类风湿性关节炎 (RA) 发病机制中的潜在作用。

信号素包括一组结构相似的分子，特征是存在约500个氨基酸的Sema结构域，广泛表达于免疫细胞中，并在各种免疫应答中发挥作用。该文章目的是研究信号素在类风湿性关节炎 (RA) 发病机制中的潜在作用。

方法：在Affymetrix GeneChip人外显子1.0 ST阵列上对来自RA循环祖细胞的内皮细胞(EC)和对照EC进行微阵列实验。RA患者和健康对照的第三类和第四类信号素表达通过滑膜组织的免疫组织化学评估，血清中信号素受体的表达通过酶联免疫吸附试验测量。

结果：微阵列分析揭示了在RA ECs中第3类和第4类信号素及其受体的差异表达。RA ECs的信号素4A (SEMA4A)、丛素D1和神经纤毛蛋白1的mRNA水平与对照ECs相比分别显著增加1.75，2.21和1.68倍。用肿瘤坏死因子(TNF)刺激RA ECs，SEMA4A mRNA 水平增加2倍。SEMA4A低表达改变RA EC血管生成的特性。第三类和第四类信号素及其受体在RA滑膜组织中过度表达。在RA患者的血清中，SEMA4A和SEMA3E分别增加1.30倍和1.54倍，SEMA3A降低了24%。SEMA4A、SEMA4D和SEMA3A的血清水平与炎症和促血管生成标志物的水平相关。在2个独立的疾病活动度低或RA缓解的患者队列中，SEMA4A可识别具有残留疾病活动性的患者。

结论：

通过RA ECs的基因表达谱发现第3类和第4类信号素可作为RA的潜在生物标志物和治疗候选靶点。信号素在RA EC、滑膜血管和血清中证实过表达，并与炎症和血管生成标志物相关。因此，信号素可能是RA EC来源的炎症和促血管生成靶点。

 

出处：

Avouac J, Pezet S, Vandebeuque E, Orvain C, Gonzalez V, Marin G, Mouterde G, Daïen C, Allanore Y. Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis. Arthritis Rheumatol. 2021 Sep;73(9):1579-1588. doi: 10.1002/art.41701. Epub 2021 Aug 6. PMID: 33605067.

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    2022-07-30 风铃821

    #Rheumatology#

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    2021-10-05 ms6390871039024434

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    2021-09-30 lmm397

    #关节炎#

    0

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    2021-09-30 ms4964546379600229

    #类风湿#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2062550, encodeId=9a1a2062550ee, content=<a href='/topic/show?id=872c15438a4' target=_blank style='color:#2F92EE;'>#Rheumatology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15438, encryptionId=872c15438a4, topicName=Rheumatology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Sat Jul 30 03:39:32 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972772, encodeId=613119e27725e, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Oct 05 01:39:32 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266317, encodeId=e118126631e8e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334303, encodeId=5647133430374, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357796, encodeId=5612135e79637, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483718, encodeId=8d851483e1861, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056036, encodeId=ee0f1056036fd, content=这又为以后类风湿关节炎靶向治疗提供了新的治疗发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfc84293490, createdName=13f0c37dm61暂无昵称, createdTime=Wed Sep 29 12:40:12 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-09-30 zhaojie88

    #ART#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2062550, encodeId=9a1a2062550ee, content=<a href='/topic/show?id=872c15438a4' target=_blank style='color:#2F92EE;'>#Rheumatology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15438, encryptionId=872c15438a4, topicName=Rheumatology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3307462, createdName=风铃821, createdTime=Sat Jul 30 03:39:32 CST 2022, time=2022-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1972772, encodeId=613119e27725e, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Tue Oct 05 01:39:32 CST 2021, time=2021-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266317, encodeId=e118126631e8e, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1334303, encodeId=5647133430374, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357796, encodeId=5612135e79637, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483718, encodeId=8d851483e1861, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Thu Sep 30 02:39:32 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1056036, encodeId=ee0f1056036fd, content=这又为以后类风湿关节炎靶向治疗提供了新的治疗发现。, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfc84293490, createdName=13f0c37dm61暂无昵称, createdTime=Wed Sep 29 12:40:12 CST 2021, time=2021-09-29, status=1, ipAttribution=)]
    2021-09-30 ms1467340776200723

    #风湿性关节炎#

    0

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    2021-09-29 13f0c37dm61暂无昵称

    这又为以后类风湿关节炎靶向治疗提供了新的治疗发现。

    0