JAHA:高血压严重程度与认知功能障碍有关

2017-01-14 xing.T MedSci原创

高血压患者认知功能障碍较为常见,并且这与高血压严重程度有关。

大多数高血压患者靶器官损害(HTN)的证据是与肾脏和心脏相关,而对于脑血管和认知功能障碍的研究相对较少。因此,本研究分析了不同阶段的高血压患者与非高血压对照者认知功能改变的差异,并将研究结果发表在心血管病领域权威杂志JAHA上。

在这个横断面研究中,研究人员对221名研究对象(71例正常血压患者和150例原发性高血压患者)进行了比较。根据血压水平或抗高血压药物使用情况将高血压患者随机分为2个阶段(HTN-1:血压为140-159/90-99mmHg或使用1或2个降压药;HTN-1:血压为≥160/100mmHg或使用≥3个降压药)。研究者对三组患者进行了比较分析:正常血压、HTN 1级和HTN 2级。评估6个主要认知领域的简易精神状态检查、蒙特利尔认知评估和一个经验证有效的综合神经心理系列测试被研究人员用来确定认知功能。


相比于正常血压和HTN 1级参与者,严重HTN组有较差的认知功能通过简易精神状态检查(26.8±2.1 vs. 27.4±2.1 vs. 28±2;P=0.004)或蒙特利尔认知评估(23.4±3.7 vs. 24.9±2.8 vs. 25.5±3.2;P<0.001)。在神经心理学测试,高血压患者在语言、处理速度、视觉空间能力、记忆方面表现有较差。年龄、高血压分期和文化程度是高血压患者不同认知领域认知功能障碍的最佳预测因子。

由此可见,高血压患者认知功能障碍较为常见,并且这与高血压严重程度有关。

原始出处:


Henrique C.S. Muela,et al. Hypertension Severity Is Associated With
Impaired Cognitive Performance
. JAHA.January 11, 2017. 

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Jan 15 10:14:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170458, encodeId=68051e045846, content=为了高血压的标准可能还要降低,收缩压可能会控制在135或者130以内, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:19:06 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170381, encodeId=ca391e03819a, content=大多数高血压患者靶器官损害(HTN)的证据是与肾脏和心脏相关,而对于脑血管和认知功能障碍的研究相对较少, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], 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    2017-01-24 李东泽

    很好,不错,以后会多学习

    0

  2. 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    2017-01-16 1dd8aa01m06(暂无匿称)

    很好的文献,学习了

    0

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authenticateStatus=null, createdAvatar=, createdBy=62d381629, createdName=yafeiliutjh, createdTime=Sat Jan 14 20:34:48 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-16 zhaohui6731
  4. 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  5. 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    2017-01-15 tanxingdoctor

    很不错,谢谢分享

    0

  6. 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authenticateStatus=null, createdAvatar=, createdBy=62d381629, createdName=yafeiliutjh, createdTime=Sat Jan 14 20:34:48 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-15 flysky120

    学习一下知识

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Jan 15 10:14:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170458, encodeId=68051e045846, content=为了高血压的标准可能还要降低,收缩压可能会控制在135或者130以内, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:19:06 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170381, encodeId=ca391e03819a, content=大多数高血压患者靶器官损害(HTN)的证据是与肾脏和心脏相关,而对于脑血管和认知功能障碍的研究相对较少, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Sat Jan 14 23:00:17 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170360, encodeId=f2671e03604d, content=谢谢分享!!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Sat Jan 14 20:44:37 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170352, encodeId=78901e035225, content=新知识?, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62d381629, createdName=yafeiliutjh, createdTime=Sat Jan 14 20:34:48 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-15 lovetcm

    为了高血压的标准可能还要降低,收缩压可能会控制在135或者130以内

    0

  8. 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encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Mon Jan 16 04:43:00 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170568, encodeId=aa8b1e0568b7, content=很不错,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Sun Jan 15 19:20:48 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170479, encodeId=74cc1e0479c5, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sun Jan 15 10:14:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170458, encodeId=68051e045846, content=为了高血压的标准可能还要降低,收缩压可能会控制在135或者130以内, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jan 15 09:19:06 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170381, encodeId=ca391e03819a, content=大多数高血压患者靶器官损害(HTN)的证据是与肾脏和心脏相关,而对于脑血管和认知功能障碍的研究相对较少, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], 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    2017-01-14 inter158

    大多数高血压患者靶器官损害(HTN)的证据是与肾脏和心脏相关,而对于脑血管和认知功能障碍的研究相对较少

    0

  9. 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    2017-01-14 知难而进

    谢谢分享!!!!!!

    0

  10. 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    2017-01-14 yafeiliutjh

    新知识?

    0