Advanced Biosystems:哈佛科学家研发捕捉癌细胞的“新武器”,癌症大战胜券在握!

2017-06-29 佚名 medicalxpress

恶性肿瘤是强大的敌人,它们促使血管帮助它们贪婪的增长,损伤邻近组织,并部署许多策略来逃避人体的防御系统。更可恶的是循环肿瘤细胞(CTC)的释放,暗地里在血液中移动,并流窜到身体的其他部位,这一过程也就是癌症的转移。CTC虽然危险,但是他们的存在也是一个病人疾病阶段有价值的指标。不幸的是,在数万亿的健康细胞中找到相对少数CTC犹如大海捞针。

恶性肿瘤是强大的敌人,它们促使血管帮助它们贪婪的增长,损伤邻近组织,并部署许多策略来逃避人体的防御系统。更可恶的是循环肿瘤细胞(CTC)的释放,暗地里在血液中移动,并流窜到身体的其他部位,这一过程也就是癌症的转移。CTC虽然危险,但是他们的存在也是一个病人疾病阶段有价值的指标。不幸的是,在数万亿的健康细胞中找到相对少数CTC犹如大海捞针。

为了解决这个问题,哈佛大学WYSS研究所的研究人员研发了一个改造人类血液调理素的蛋白质,这种蛋白质称为FcMBL,最初是作为一种广谱病原体捕获剂,靶向CTC。研究人员使用涂有FcMBL的磁珠,能够成功捕获90%七种不同类型的癌细胞。


研究人员表示:“我们能够把CTC从血液迅速隔离,这项新技术对癌症的诊断是非常有用的,是一种非常先进的生物系统。此次研究预示着癌症战争新武器的诞生。在此次试验中,研究者在乳腺癌小鼠体内植入荧光标记物,待肿瘤发展28天,使用血液测试来确定CTC的数量,然后他们混合的血液FcMBL包裹的珠子,并让珠子悬浮磁铁中,通过测量正常细胞与癌细胞的运动速度,我们的磁珠正好附着于运动较快的癌细胞上。接着我们有对其他类型的癌症进行测试,包括非小细胞肺癌,胶质母细胞瘤等,同样适用,相信通过进一步的论证,我们的新武器可能成为未来检测癌症的新工具。”

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    2017-11-09 wwzzly
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encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Sat Jul 01 00:47:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216715, encodeId=565a216e15f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 29 15:04:23 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-11-10 gongliu
  5. 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encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Sat Jul 01 00:47:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216715, encodeId=565a216e15f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 29 15:04:23 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-11-26 sunylz
  6. 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encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Sat Jul 01 00:47:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216715, encodeId=565a216e15f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 29 15:04:23 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-07-01 yxch36
  7. 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encryptionId=7bec398e2e6, topicName=哈佛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c7014916331, createdName=amyloid, createdTime=Sat Jul 01 00:47:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216715, encodeId=565a216e15f8, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 29 15:04:23 CST 2017, time=2017-06-29, status=1, ipAttribution=)]
    2017-07-01 lqvr
  8. 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  9. 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    2017-07-01 amyloid
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    2017-06-29 189****7206

    学习了谢谢分享

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