Hypertension:家庭血压变异性或可预测认知减退

2014-04-04 高晓方 译 医学论坛网

日本一项研究表明,由于家庭血压测定可提供每日血压变异性信息,因此可用于预测未来认知减退。论文于3月31日在线发表于《高血压》(Hypertension)。此项前瞻性研究共纳入485例平均年龄为63岁的受试者。基线时受试者均无认知减退。测定受试者家庭血压,并计算每日血压变异性。评估家庭血压对认知减退的预测价值,以及每日血压变异性能否更好预测认知减退。中位随访时间为7.8年。结果显示,46例受试者在随

日本一项研究表明,由于家庭血压测定可提供每日血压变异性信息,因此可用于预测未来认知减退。论文于3月31日在线发表于《高血压》(Hypertension)。

此项前瞻性研究共纳入485例平均年龄为63岁的受试者。基线时受试者均无认知减退。测定受试者家庭血压,并计算每日血压变异性。评估家庭血压对认知减退的预测价值,以及每日血压变异性能否更好预测认知减退。中位随访时间为7.8年。

结果显示,46例受试者在随访期间出现认知减退。家庭收缩压升高与认知减退具有显著相关性(比值比[OR] 1.48),常规收缩压则与认知减退无显著相关性(OR 1.24)。在模型中纳入家庭收缩压后,收缩压每日变异性与认知减退显著相关;尽管家庭收缩压OR仍为阳性,但显著性消失。

原始出处:


Matsumoto A1, Satoh M, Kikuya M, Ohkubo T, Hirano M, Inoue R, Hashimoto T, Hara A, Hirose T, Obara T, Metoki H, Asayama K, Hosokawa A, Totsune K, Hoshi H, Hosokawa T, Sato H, Imai Y.Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline: The Ohasama Study.Hypertension. 2014 Mar 31.

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    2014-05-18 feather89
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