Diabetes Care:青少年DM患者多发性硬化症发病风险高

2013-09-09 佚名 丁香园

在儿童及青少年中,1型糖尿病和多发性硬化症(MS)是典型的自身免疫性疾病。为了评价1型糖尿病并发MS的情况(通过估计儿童和青少年糖尿病人群的MS相对风险来进行),并寻找可能的影响因素,来自德国慕尼黑大学医学院儿科的Bechtold博士等进行了一项研究,研究发现,儿童和青少年糖尿病人群并发MS的风险较高。移民背景和甲状腺抗体是预测MS发病率的独立风险指标,环境因素可调节个人并发这两种疾病的风险。研究

在儿童及青少年中,1型糖尿病和多发性硬化症(MS)是典型的自身免疫性疾病。为了评价1型糖尿病并发MS的情况(通过估计儿童和青少年糖尿病人群的MS相对风险来进行),并寻找可能的影响因素,来自德国慕尼黑大学医学院儿科的Bechtold博士等进行了一项研究,研究发现,儿童和青少年糖尿病人群并发MS的风险较高。移民背景和甲状腺抗体是预测MS发病率的独立风险指标,环境因素可调节个人并发这两种疾病的风险。研究结果在线发表于2013年8月29日的美国《糖尿病治疗》(Diabetes Care)杂志上。【原文下载

研究数据来自DPV-Wiss项目数据库,研究人员收集了1995年1月至2012年10月德国和奥地利248个中心的56,653名1型糖尿病患者的数据。选取已发表的德国和中欧MS患病率的数据用于比较。采用多变量线性回归分析鉴定1型糖尿病合并MS的混杂因素。

结果显示,1型糖尿病患者MS相对风险估计为3.35到4.79。DPV数据库中MS发病率的影响因素可能是移民情况(P<0.05)和男性患者的甲状腺抗体(P=0.05)。与1型糖尿病人群比较,1型糖尿病合并MS患者出生月份多分布春天和夏天。

研究表明,儿童和青少年糖尿病人群并发MS的风险较高。移民背景和男性患者的甲状腺抗体是预测MS发病率的独立风险指标。在春天和夏天出生的糖尿病患者发生MS的风险较高,环境因素可调节个人并发这两种疾病的风险。

原文下载

Bechtold S, Blaschek A, Raile K, Dost A, Freiberg C, Askenas M, Fröhlich-Reiterer E, Molz E, Holl RW.Higher Relative Risk for Multiple Sclerosis in a Pediatric and Adolescent Diabetes Population: Analysis From DPV Data Base.Diabetes Care. 2013 Aug 29

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    2013-11-01 jml2009
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