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Sci Rep：利用微卫星分析技术认识肾血管平滑肌脂肪瘤的起源与局部淋巴结的参与

2017-03-29 AlexYang MedSci原创

肾血管平滑肌脂肪瘤微卫星分析淋巴结
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涉及局部淋巴结（LN）的肾血管平滑肌脂肪瘤（AML）能够引起转移问题和多中心起源的问题，并且它们的组织学特征类似。基因组不稳定性是癌症的一个普遍特性。最近，因此研究人员假设个体病人的肿瘤的独立出现应该具有可以检测的基因组变化，从而促进对肿瘤谱系和相关性的区分和认识。研究人员将12名诊断为淋巴结结点相关的肾血管平滑肌脂肪瘤患者作为研究群体，并且这些患者来自中国西部。研究人员利用6个微卫星标记，通过P

涉及局部淋巴结（LN）的肾血管平滑肌脂肪瘤（AML）能够引起转移问题和多中心起源的问题，并且它们的组织学特征类似。

基因组不稳定性是癌症的一个普遍特性。因此，研究人员假设个体病人的肿瘤的独立出现应该具有可以检测的基因组变化，从而促进对肿瘤谱系和相关性的区分和认识。研究人员将12名诊断为淋巴结结点相关的肾血管平滑肌脂肪瘤患者作为研究群体，并且这些患者来自中国西部。研究人员利用6个微卫星标记，通过PCR分析，对从不同个体获得的肾脏和淋巴结切片的基因组进行了检测分析从而鉴定不同的等位基因改变。研究结果表明，在跟踪调查期间，这12位病人经历了外科手术治疗并且没有病人出现局部复发或者大规模转移现象。其中，10个病人展现出一致的趋势，即来源于肾血管平滑肌脂肪瘤样本DNA的PCR检测与6个微卫星标记带型一致。但在对应的LN样本DNA中，带型却减少或者没有观察到。从这个技术来看，肾脏AMLs与LN的联系并不能被排除。因此，研究人员指出，当在医学图像中发现增大了的LN， 积极的监控是必须的。还指出了如果增大的LN在外科手术中发现，那么也许可以通过LN切除术来证明其病理学性质。

原始出处：

Ping Tan，Huan Xu， Yong Jiang et al. Microsatellite analysis for differentiating the origin of renal angiomyolipoma and involved regional lymph node. Sci Rep. 23 March 2017. doi：10.1038/s41598-017-00460-w

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    2017-04-15 qjddjq

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    2017-12-22 anan

    #血管平滑肌#

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    2017-07-19 shijzhiewnjhch

    #平滑肌#

    0

  4. 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style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-04-01 小驹

    肾肿瘤也有MSI?

    0

  5. 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style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-04-01 sword20000

    受教了!

    0

  6. 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topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573169, encodeId=2f1715e31695e, content=<a href='/topic/show?id=3ad382e474a' target=_blank style='color:#2F92EE;'>#肾血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82747, encryptionId=3ad382e474a, topicName=肾血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9aa615815907, createdName=syscxl, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623972, encodeId=8b8016239e2fc, content=<a href='/topic/show?id=395789628eb' target=_blank style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 sodoo

    #淋巴结#

    0

  7. 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style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 lilili1104

    #脂肪瘤#

    0

  8. 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topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573169, encodeId=2f1715e31695e, content=<a href='/topic/show?id=3ad382e474a' target=_blank style='color:#2F92EE;'>#肾血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82747, encryptionId=3ad382e474a, topicName=肾血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9aa615815907, createdName=syscxl, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623972, encodeId=8b8016239e2fc, content=<a href='/topic/show?id=395789628eb' target=_blank style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 chg122

    #局部#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2078497, encodeId=9f3920e849748, content=<a href='/topic/show?id=9cf9505582e' target=_blank style='color:#2F92EE;'>#微卫星#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50558, encryptionId=9cf9505582e, topicName=微卫星)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Sat Apr 15 15:50:00 CST 2017, time=2017-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028548, encodeId=551e20285480d, content=<a href='/topic/show?id=35da896260d' target=_blank style='color:#2F92EE;'>#血管平滑肌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89626, encryptionId=35da896260d, topicName=血管平滑肌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=236b481, 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384770, encodeId=5f4d1384e703f, content=<a href='/topic/show?id=27348436847' target=_blank style='color:#2F92EE;'>#脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84368, encryptionId=27348436847, topicName=脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=afdf491, createdName=lilili1104, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405715, encodeId=f0001405e15ea, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, 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style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 syscxl

    #肾血管平滑肌脂肪瘤#

    0

  10. 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style='color:#2F92EE;'>#血管平滑肌脂肪瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89628, encryptionId=395789628eb, topicName=血管平滑肌脂肪瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fec120619464, createdName=drj2010, createdTime=Fri Mar 31 07:50:00 CST 2017, time=2017-03-31, status=1, ipAttribution=)]
    2017-03-31 drj2010

    #血管平滑肌脂肪瘤#

    0

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FDA批准依维莫司治疗结节性硬化症相关性肾肿瘤

       2012年4月26日，诺华公司与美国食品药品管理局(FDA)宣布，已批准Afinitor(依维莫司)用于治疗结节性硬化症(TSC)患者的不必立即手术的肾血管平滑肌脂肪瘤。该药的申请得到了FDA的优先审查，后者适用于带来重要进展的药物或目前无法有效治疗的疾病的新治疗手段。        Afini