阜外医院肺动脉血栓内膜剥脱术经验:3/4可达到彻底剥脱

2019-09-02 佚名 中国循环杂志

目前,肺动脉血栓内膜剥脱术是治疗慢性血栓栓塞性肺动脉高压(CTEPH)患者的最佳治疗方式,术后肺动脉压力阻力改善情况是影响肺动脉血栓内膜剥脱术远期预后的主要因素。

目前,肺动脉血栓内膜剥脱术是治疗慢性血栓栓塞性肺动脉高压(CTEPH)患者的最佳治疗方式,术后肺动脉压力阻力改善情况是影响肺动脉血栓内膜剥脱术远期预后的主要因素。

阜外医院刘盛、宋云虎等开展的一项研究表明,术后残存堵塞肺段数在0~2个为理想的残存堵塞肺段数,此时可获得最佳的血流动力学改善结果。

研究者认为,术后残存堵塞肺段数在2 段及以下为肺动脉血栓内膜剥脱彻底的标志。该研究中约76.7%的患者获得了彻底剥脱。

研究还发现,术前有深静脉血栓病史的患者术后往往能获得理想数量的残存血栓。

研究者指出,对于手术开展时间不长的中心,在收治无明显深静脉血栓病史的患者时,需谨慎安排此类手术。

该研究入组87例于阜外医院诊断为慢性血栓栓塞性肺动脉高压并接受肺动脉血栓内膜剥脱术的患者。

根据术后CT 提示残存堵塞肺段数,将患者分为0~2 段组、3~4 段组、5~6 段组和7~8 段组;根据出现明显血流动力学变化差异的残存堵塞肺段数临界值,将患者分为肺血栓残存过多组(20例)及肺血栓残存理想组(66例)。

肺血栓残存理想组在术后血流动力学及三尖瓣反流改善方面均明显优于肺血栓残存过多组。

单因素分析提示,手术年份(OR=0.905)及术前合并深静脉血栓性疾病(OR=0.261)是影响肺血栓残存程度的主要保护性因素。

多因素分析结果提示,术前合并深静脉血栓性疾病患者为影响剥脱肺血栓残存分组的主要保护性影响因素(OR=0.289)。

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