Diabetologia：瑞典人群中与2型糖尿病相关的血浆代谢物

2018-05-31 MedSci MedSci原创

近日，国际杂志《Diabetologia》上在线发表一项关于瑞典人群中与2型糖尿病相关的血浆代谢物的前瞻性队列中的病例对照研究。研究的目的是确定预测未来2型糖尿病的血浆代谢物，鉴定后来发展或未发展成2型糖尿病个体的代谢物的变化，并评估哪种代谢物在什么程度上能改善风险预测。研究人员在瑞典基于人群的Västerbotten干预计划队列中建立了巢式病例对照研究。使用非靶向液相色谱 -

近日，国际杂志《Diabetologia》上在线发表一项关于瑞典人群中与2型糖尿病相关的血浆代谢物的前瞻性队列中的病例对照研究。研究的目的是确定预测未来2型糖尿病的血浆代谢物，鉴定后来发展或未发展成2型糖尿病个体的代谢物的变化，并评估哪种代谢物在什么程度上能改善风险预测。研究人员在瑞典基于人群的Västerbotten干预计划队列中建立了巢式病例对照研究。使用非靶向液相色谱 -质谱代谢组学分析了503名病例，包括在基线（中位时间为诊断前7年）的对照组患者血浆样本和10年随访期间187个病例的对照组的样本。使用适用于大规模代谢组学的多变量数据分析，这是区别病例与对照之间的代谢物的最佳选择。使用条件逻辑回归来评估有识别能力代谢物与未来2型糖尿病之间的关联，并针对几种已知的危险因素进行校正。使用组内相关性估计10年内健康参与者子集中确定的代谢物的重复性；使用混合模型研究了他们在发生2型糖尿病的患者中随时间的系统变化与诊断的关系。使用ROC曲线下的面积，区分改善指数和净重新分类指数评估由不同预测因子构成的模型的风险预测性能。研究人员鉴定了46种预测性2型糖尿病的血浆代谢物。在新发现的

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2019-04-21 旅苦化文_216

#代谢物#

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2019-01-22 ms9608593228839890

#DIA#

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2018-09-20 zz70

#血浆代谢物#

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2019-03-31 ms5439512287675881

#BET#

57 0
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2018-06-04 yfjms

学习

56 0
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2018-06-01 惠映实验室

学习了.谢谢分享.

70 0
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2018-05-31 虈亣靌

学习了.获益匪浅.感谢分享

64 0

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