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Diabetologia：葡萄糖依赖的胰岛素促胰岛素肽与心血管事件和死亡的风险:一项前瞻性研究

2020-07-20 MedSci原创 MedSci原创

心血管事件；死亡；风险
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有证据表明葡萄糖依赖的胰岛素促胰岛素肽(GIP)和/或GIP受体(GIPR)与心血管生物学有关。

有证据表明葡萄糖依赖的胰岛素促胰岛素肽(GIP)和/或GIP受体(GIPR)与心血管生物学有关。与胰高血糖素样肽1 (GLP-1)相比，本研究假设GIP对心血管生物学有不利影响，因此对GIP和GLP-1浓度对心血管疾病(CVD)和死亡风险的影响进行了研究。

在两个独立的人群(Malmo Diet癌症-心血管队列[MDC-CC]和博特尼亚的糖尿病患病率、预测和预防[ppp -博特尼亚])中，测量了GIP浓度，共包括8044名受试者。在MDC-CC中测定GLP-1 (n = 3625)。通过国家/区域登记或问卷进行评估心血管疾病的发病率和死亡率。此外，利用GIP相关的基因变异rs1800437作为工具变量，对GIP通路和预后(冠心病和心肌梗死)进行了两样本孟德尔随机化(2SMR)分析。另外以CAD为暴露变量，GIP为结局变量进行逆向2SMR，由114个已知的CAD遗传风险变异体构建工具变量。

在荟萃分析中，空腹较高的GIP水平与较高的总死亡率风险相关(HR[95% CI] = 1.22 [1.11, 1.35];p = 4.5×10−5)和死于心血管疾病(HR 1.30(95%置信区间)[1.11,1.52];p = 0.001)。因此，2SMR分析显示，GIP浓度升高与冠心病和心肌梗死有关，而另一个反向2SMR显示，冠心病对GIP水平没有显著影响，从而证实了GIP单独对冠心病的影响。

研究结果表明，在两项以社区为基础的前瞻性研究中，GIP水平升高与随访5-9年内全因和心血管死亡风险增加有关，而GLP-1水平与过度风险无关。进一步的研究需要确定GIP本身对心血管的影响。

原始出处：

Amra Jujić, Naeimeh Atabaki-Pasdar,Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality: a prospective study

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    2021-01-26 ms5439512287675881

    #BET#

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    2021-03-28 baoya

    #胰岛#

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    2021-05-02 hukaixun

    #血管事件#

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    2021-03-25 ms9608593228839890

    #DIA#

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    2020-09-26 lhlxtx

    #前瞻性研究#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1761449, encodeId=7e471e61449a4, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Jan 26 09:20:16 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750162, encodeId=1b201e50162d8, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sun Mar 28 06:20:16 CST 2021, time=2021-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1643710, encodeId=dfff1643e1008, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sun May 02 19:20:16 CST 2021, time=2021-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639525, encodeId=443b163952566, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Mar 25 16:20:16 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1914478, encodeId=3e0619144e8b9, content=<a href='/topic/show?id=103f3264681' target=_blank style='color:#2F92EE;'>#前瞻性研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32646, encryptionId=103f3264681, topicName=前瞻性研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Sat Sep 26 23:20:16 CST 2020, time=2020-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006495, encodeId=927e200649576, content=<a href='/topic/show?id=924a3264381' target=_blank style='color:#2F92EE;'>#前瞻性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32643, encryptionId=924a3264381, topicName=前瞻性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5cb32500112, createdName=1508842480_96220437, createdTime=Wed Jun 09 19:20:16 CST 2021, time=2021-06-09, status=1, ipAttribution=)]
    2021-06-09 1508842480_96220437

    #前瞻性#

    0