JCEM:青少年肥胖与机体spexin激素 分泌较少有关?

2016-05-26 MedSci MedSci原创

来自梅奥诊所的一项新的研究表明,肥胖青少年体内的一种激素spexin 分泌量较低,该研究成果已发表于Journal of Clinical Endocrinology & Metabolism。在过去的30年里,美国肥胖率明显上升,导致2型糖尿病、中风和心脏病的发病率升高。据CDC显示,201年约21%的美国青少年(12-19岁)肥胖,而1980年仅为5%。尽管不良的饮食习惯和缺乏运动时导

来自梅奥诊所的一项新的研究表明,肥胖青少年体内的一种激素spexin 分泌量较低,该研究成果已发表于Journal of Clinical Endocrinology & Metabolism。

在过去的30年里,美国肥胖率明显上升,导致2型糖尿病、中风和心脏病的发病率升高。


据CDC显示,201年约21%的美国青少年(12-19岁)肥胖,而1980年仅为5%。

尽管不良的饮食习惯和缺乏运动时导致肥胖的关键因素,但是研究已经发现或许还有其他的因素导致肥胖的发生,如家族肥胖史。

研究人员还建议,激素spexin——参与调节机体能量平衡和脂肪质量,在肥胖的发生中发挥着重要的作用;既往研究已经确定成年肥胖患者中该激素的分泌量较少。

该研究的资深作者Seema Kumar博士指出,该研究首次探究了spexin在肥胖青少年中的作用。

Spexin水平最低时肥胖的发生风险增加5.25倍

该项研究中,研究人员分析了69名年龄在12-18岁之间的参与者血液中spexin的水平,其中51名肥胖青少年和18名正常体重的青少年。根据 spexin的水平将其分为四组。

结果发现,肥胖青少年的spexin水平低于体重正常者。与spexin水平最高的参与者相比,spexin水平最低的参与者肥胖的发生风险增加了5.25倍。

既往成人中spexin的研究已经确定spexin的水平与空腹血糖的水平有关,但是本研究并未发现此关联。
Kumar博士说道,这些研究表明,spexin或在生命早期阶段便参与了机体的体重增加。

最后她补充道,“值得注意的是,在肥胖青少年和体重正常的青少年中,我们科清楚观察到spexin激素水平的明显差异。”

由于该研究为横断面研究,因此仍需要大量的研究来探究spexin的生理学意义,以及spexin如何参与了儿童肥胖的发生,以及spexin是否可用于帮助儿童治疗或管理肥胖。

原始出处:

Kumar S, Hossain J, Nader N, Aguirre R, Sriram S, Balagopal PB. Decreased Circulating Levels of Spexin in Obese Children. J Clin Endocrinol Metab. 2016 May 24:jc20161177

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    2017-03-15 feather89
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    2016-12-26 smallant2015
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    2017-04-17 gwc392
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    2016-08-29 ylzr123

    深度好文,值得学习,赞!

    0

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    2016-09-01 achengzhao
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    2016-06-02 沉心多思

    好文章,得多学习了!

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