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Exp Clin Endocrinol Diabetes：多囊卵巢综合征与前列腺素水平升高有关

2020-10-01 MedSci原创 MedSci原创

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卵巢周蛋白是一种分泌的细胞外基质蛋白，与甘油三酯代谢、慢性炎症和胰岛素抵抗密切相关。越来越多的证据表明，肌周蛋白与卵巢功能之间存在联系。本次横断面研究旨在确定多囊卵巢综合征(PCOS)妇女的循环过氧化

卵巢周蛋白是一种分泌的细胞外基质蛋白，与甘油三酯代谢、慢性炎症和胰岛素抵抗密切相关。越来越多的证据表明，肌周蛋白与卵巢功能之间存在联系。本次横断面研究旨在确定多囊卵巢综合征(PCOS)妇女的循环过氧化物酶水平是否发生改变，并进一步探讨PCOS患者过氧化物酶与糖代谢紊乱的关系，研究结果已在线发表于Exp Clin Endocrinol Diabetes。

研究共招募50名PCOS女性和30名年龄匹配的非PCOS对照组。同时采用ELISA法测定围素水平。

 

结果显示，与对照组相比，PCOS妇女循环中的围素水平显著升高[4206.75(222.00，4815.25)vs.430.75(142. 13，730.86)ng/ml，P=0. 005]。Spearman相关分析显示，血清中的胰岛素水平与体重指数(BMI)、尿酸、胰岛素抵抗的稳态模型评估(HOMA-IR)、高敏C反应蛋白(hs-CRP)呈正相关，与胰岛素敏感性指数(ISI)呈负相关。Logistic回归模型显示，PCOS与腰臀比(WHR)、空腹血糖(FBG)和胰岛素水平相关。此外，多变量线性回归分析显示，FBG、HOMA-IR和脂质累积指数（LAP）是影响血清周蛋白水平的独立因素。

 

综上所述，该研究结果表明，PCOS与卵巢周蛋白水平升高有关。

 

原始出处：

 

Xinwei Chen, Lijing Huo, et al., Polycystic Ovary Syndrome is Associated with Elevated Periostin Levels. Exp Clin Endocrinol Diabetes. 2019 Oct;127(9):571-577. doi: 10.1055/a-0752-0061.

 

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    2021-07-07 ms5439512287675881

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    2020-11-03 makuansheng

    #前列腺素#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1761517, encodeId=c3841e61517f9, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jul 07 17:33:48 CST 2021, time=2021-07-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718432, encodeId=5e4a1e1843293, content=<a href='/topic/show?id=5ce04315043' target=_blank style='color:#2F92EE;'>#多囊卵巢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43150, encryptionId=5ce04315043, topicName=多囊卵巢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c91632558486, createdName=kalseyzl, createdTime=Thu Aug 05 01:33:48 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639617, encodeId=0618163961e1e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Fri Nov 27 09:33:48 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902497, encodeId=f9b6190249ef5, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Fri Feb 19 17:33:48 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744867, encodeId=e79c1e448671c, content=<a href='/topic/show?id=37c3325555a' target=_blank style='color:#2F92EE;'>#前列腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32555, encryptionId=37c3325555a, topicName=前列腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6e7035453721, createdName=makuansheng, createdTime=Tue Nov 03 20:33:48 CST 2020, time=2020-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431949, encodeId=a4c91431949e4, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sat Oct 03 14:33:48 CST 2020, time=2020-10-03, status=1, ipAttribution=)]
    2020-10-03 zhouqu_8

    #综合征#

    0