J Indian Soc Periodontol:白细胞介素-21及其与慢性牙周炎的关系

2019-02-07 MedSci MedSci原创

白细胞介素-21(IL-21)是一种多效细胞因子,多项研究已经证实Th17细胞的发育在牙周炎的发病机制中起重要作用。牙周病是牙齿支持组织的慢性感染。本研究评估慢性牙周炎和牙周健康个体患者的唾液和血清IL-21水平。 每组50个样品包括在本研究中。使用市售的酶联免疫吸附测定(ELISA)试剂盒评估IL-21的水平,结果表示为pg / mL。使用SPSS 17.0软件进行统计学分析。数据表示为平均值±

白细胞介素-21(IL-21)是一种多效细胞因子,多项研究已经证实Th17细胞的发育在牙周炎的发病机制中起重要作用。牙周病是牙齿支持组织的慢性感染。本研究评估慢性牙周炎和牙周健康个体患者的唾液和血清IL-21水平。

每组50个样品包括在本研究中。使用市售的酶联免疫吸附测定(ELISA)试剂盒评估IL-21的水平,结果表示为pg / mL。使用SPSS 17.0软件进行统计学分析。数据表示为平均值±标准偏差和四分位数范围以及对照和病例的比较,通过Mann-Whitney检验。

结果显示,慢性牙周炎组血清和唾液中IL-21水平显著高于对照组(P <0.001)。临床牙周参数与血清IL-21水平呈正相关。

总之,该研究结果表明,IL-21在慢性牙周炎患者中高表达,并且与牙周破坏的临床参数相关。因此,IL-21似乎在组织破坏中起作用,并且可以用作慢性牙周炎的诊断生物标志物。唾液可被认为是血清作为诊断样品的有用替代品。

原始出处:

Lokhande RV, Ambekar JG, et al., Interleukin-21 and its association with chronic periodontitis. J Indian Soc Periodontol. 2019 Jan-Feb;23(1):21-24. doi: 10.4103/jisp.jisp_410_18.

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GetPortalCommentsPageByObjectIdResponse(id=360090, encodeId=ac2d36009071, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 07 07:25:50 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-08 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

  5. 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  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=360090, encodeId=ac2d36009071, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 07 07:25:50 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-08 xiaogang319
  8. 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  9. 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GetPortalCommentsPageByObjectIdResponse(id=360090, encodeId=ac2d36009071, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Thu Feb 07 07:25:50 CST 2019, time=2019-02-07, status=1, ipAttribution=)]
    2019-02-07 flysky120

    白细胞的牙齿作用

    0

  10. 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