Heart:抗磷脂抗体可预测感染性心内膜炎患者预后

2018-03-02 MedSci MedSci原创

抗磷脂(aPL)抗体可以激活血小板,并在感染性心内膜炎(IE)的发展和血栓形成中起到重要作用。本研究的目的旨在评估aPL作为预测IE患者血栓事件(EE)发生的因子的可行性。本研究纳入了Nanc-IE数据库中的186名确诊为IE的患者,在患者入组后对其进行抗心磷脂(aCL)和抗β2-糖蛋白I(β2GPI)抗体的检测。分析结果发现,在118名(63%)患者中检测到至少一次EE的发生,在31名(17%)

抗磷脂(aPL)抗体可以激活血小板,并在感染性心内膜炎(IE)的发展和血栓形成中起到重要作用。本研究的目的旨在评估aPL作为预测IE患者血栓事件(EE)发生的因子的可行性。本研究纳入了Nanc-IE数据库中的186名确诊为IE的患者,在患者入组后对其进行抗心磷脂(aCL)和抗β2-糖蛋白I(β2GPI)抗体的检测。分析结果发现,在118名(63%)患者中检测到至少一次EE的发生,在31名(17%)患者中检测到aPL抗体,并且在anti-β2GPI抗体阳性的患者中,EE发生的频率要更高(P=0.0036)。能预测EE发生的因子有anti-β2GPIIgM(HR=3.45 (1.47-8.08), P=0.0045)、肌酸酐(2.74 (1.55-4.84), P=0.0005)和感染面积(2.41 (1.41-4.12), P=0.0014),而预测大脑血栓的因子有aCLIgM(2.84 (1.22-6.62), P=0.016)和anti-β2GPIIgM(4.77 (1.79-12.74), P=0.0018)。研究结果显示,抗心磷脂和抗β2-糖蛋白I的抗体与感染性心内膜炎患者血栓栓

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    2018-03-05 大爰

    学习了谢谢分享!!

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=292331, encodeId=a9aa292331ac, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Mar 02 17:23:50 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-04 zhaojie88
  8. [GetPortalCommentsPageByObjectIdResponse(id=1655416, encodeId=92e8165541645, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Wed May 09 08:03:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708443, encodeId=cf091e0844321, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, 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target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Mar 04 01:03:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292554, encodeId=66cd2925544b, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:29:13 CST 2018, time=2018-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292331, encodeId=a9aa292331ac, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Fri Mar 02 17:23:50 CST 2018, time=2018-03-02, status=1, ipAttribution=)]
    2018-03-04 slcumt
  9. 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    2018-03-03 惠映实验室

    学习.谢谢分享.

    0

  10. 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target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Mar 04 01:03:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292554, encodeId=66cd2925544b, content=学习.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat Mar 03 09:29:13 CST 2018, time=2018-03-03, status=1, ipAttribution=), 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    2018-03-02 yfjms

    学习

    0

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JAHA:心脏的康复训练能改善腹部动脉瘤患者预后

目前尚无报道阐述体育锻炼对小型腹部动脉瘤(AAA)患者的影响。本研究纳入了2004年至2015年1515名小型AAA的术前患者,一种精心调整的心脏康复方案被应用在50名患者中,并且在运动过程中没有过高的血压升高。最终评估心脏康复组和非康复组患者的死亡率和临床预后(包括动脉瘤的扩张率)的差异。心脏康复组患者(n=49)和非康复组(n=163)的人口统计学特征一致。分析结果发现AAA修复的风险在康复组

JACC:丙磺舒在治疗高龄痛风患者中心血管发生风险更小

痛风患者发生心血管疾病的风险大大增高。本研究的目的旨在比较评估痛风患者接受的两者不同药物治疗(丙磺舒和别嘌呤醇)在心血管方面的安全性。本研究纳入了2008年至2013年年龄≥65岁服用丙磺舒或别嘌呤醇治疗的痛风患者,主要终点事件是心梗和卒中的复合住院治疗,次要终点事件是心梗、卒中、冠脉血运重建、心衰和死亡。最终,共纳入分析了9722名接受丙磺舒治疗的患者,29166名接受别嘌呤醇治疗的患者,平均年

Eur Heart J:PCSK9基因的突变对卒中和冠心病有不同的影响

PCSK9基因的突变对低密度脂蛋白胆固醇(LDL-C)和冠心病的发生均有很大的影响,然而其对缺血性卒中(IS)的影响尚属未知。本研究对10307名IS患者和19326名正常对照对PCSK9功能缺失突变(rs11591147; R46L)和另外5个突变位点与IS和IS亚型之间的关系进行荟萃分析。结果发现rs11591147的T等位点可以降低0.5mmol/L 的LDL-C水平和23%的冠心病发病风险