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Science子刊：糖尿病治疗新药可延缓帕金森病进展 明年将开始临床试验

2016-12-13 佚名 生物谷

糖尿病帕金森
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一种处于临床申请阶段本来用于治疗糖尿病的新药将要用于一项帕金森病临床治疗研究，相关研究结果发表在国际学术期刊Science Translational Medicine上。到现在为止帕金森病治疗主要集中在对症状的控制。如果在人类临床试验中取得成功，MSDC-0160将成为世界上从根本上治疗这种疾病延缓疾病进展的首个治疗药物，或可实现对病人生活质量的改善，阻止认知能力下降的发生。还可以减少或推迟对药

一种处于临床申请阶段本来用于治疗糖尿病的新药将要用于一项帕金森病临床治疗研究，相关研究结果发表在国际学术期刊Science Translational Medicine上。



到现在为止帕金森病治疗主要集中在对症状的控制。如果在人类临床试验中取得成功，MSDC-0160将成为世界上从根本上治疗这种疾病延缓疾病进展的首个治疗药物，或可实现对病人生活质量的改善，阻止认知能力下降的发生。还可以减少或推迟对药物的需求，减少副作用。

MSDC-0160由美国MSDC公司开发用以治疗2型糖尿病。在2012年的时候，Patrik Brundin博士等人因为其作用模式，对人类的安全性，局部作用能力等因素将这种药物选作帕金森病治疗候选药物，经过四年的研究，这种药物在实验室条件下展现出的作用效果已经超出Brundin等人的预期。

这种药物的创新性源于最近一些研究发现帕金森病可能起源于，至少是部分起源于机体的能量代谢。这种新药可以调节脑细胞线粒体功能，能够恢复细胞将基础营养物质变为能量的能力。随后细胞对有害蛋白的处理能力恢复正常，降低了炎症和神经细胞死亡。

“帕金森病和糖尿病在症状上存在巨大不同，但是我们发现这两种疾病在分子水平上存在一些共享机制，对MSDC-1060等胰岛素增敏药物存在类似的应答反应。”文章共同作者Jerry Colca博士这样说道。

Brundin表示他很期待看到MSDC-1060治疗帕金森病的临床研究能够得到启动，他也很期待能够在其他认知下降疾病中检测这种药物的作用效果。

“这是为药物开发找到的一条极其具有前景的道路，”Brundin这样说道。

原始出处：

Anamitra Ghosh1, Trevor Tyson1, Sonia George1, Erin N. Hildebrandt1, Jennifer A. Steiner1, Zachary Madaj2, Emily Schulz1, Emily Machiela1, William G. McDonald3, Martha L. Escobar Galvis1, Jeffrey H. Kordower1,4, Jeremy M. Van Raamsdonk1, Jerry R. Colca3 and Patrik Brundin1,*Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease.Science Translational Medicine .07 Dec 2016

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1989950, encodeId=9d6a1989950cc, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Dec 21 02:33:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165588, encodeId=9920165588fc, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Dec 25 13:31:49 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375416, encodeId=b58413e5416f5, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Dec 15 00:33:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162849, encodeId=8a6916284988, content=很好，期待试验结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/nVMLr1AgPVPqCvgGl1CbPiaOLBkYK6c3zXpECMkZ0VzfbnYGFnWQ9xOly0XibiceTVGKdMJVAbX2TEz9Yt6uxvvJQ/0, createdBy=a8411981495, createdName=1e183db5m33(暂无匿称), createdTime=Wed Dec 14 22:32:26 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162515, encodeId=c71e162515d3, content=相关帕金森, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160807/IMG57A72B38A8C787546.jpg, createdBy=52b31714117, createdName=Anima, createdTime=Tue Dec 13 18:56:03 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162399, encodeId=acef16239940, content=思路很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19061994286, createdName=1e1b1150m51(暂无匿称), createdTime=Tue Dec 13 10:01:43 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-21 zhanglin3079

    #糖尿病治疗#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1989950, encodeId=9d6a1989950cc, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Dec 21 02:33:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165588, encodeId=9920165588fc, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Dec 25 13:31:49 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375416, encodeId=b58413e5416f5, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Dec 15 00:33:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162849, encodeId=8a6916284988, content=很好，期待试验结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/nVMLr1AgPVPqCvgGl1CbPiaOLBkYK6c3zXpECMkZ0VzfbnYGFnWQ9xOly0XibiceTVGKdMJVAbX2TEz9Yt6uxvvJQ/0, createdBy=a8411981495, createdName=1e183db5m33(暂无匿称), createdTime=Wed Dec 14 22:32:26 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162515, encodeId=c71e162515d3, content=相关帕金森, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160807/IMG57A72B38A8C787546.jpg, createdBy=52b31714117, createdName=Anima, createdTime=Tue Dec 13 18:56:03 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162399, encodeId=acef16239940, content=思路很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19061994286, createdName=1e1b1150m51(暂无匿称), createdTime=Tue Dec 13 10:01:43 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-25 李东泽

    很好，不错，以后会多学习

    0

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    2016-12-15 jichang

    #SCIE#

    0

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    2016-12-14 1e183db5m33(暂无匿称)

    很好，期待试验结果。

    0

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    2016-12-13 Anima

    相关帕金森

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1989950, encodeId=9d6a1989950cc, content=<a href='/topic/show?id=3207e6735ae' target=_blank style='color:#2F92EE;'>#糖尿病治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76735, encryptionId=3207e6735ae, topicName=糖尿病治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Wed Dec 21 02:33:00 CST 2016, time=2016-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=165588, encodeId=9920165588fc, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Dec 25 13:31:49 CST 2016, time=2016-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375416, encodeId=b58413e5416f5, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Dec 15 00:33:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162849, encodeId=8a6916284988, content=很好，期待试验结果。, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/nVMLr1AgPVPqCvgGl1CbPiaOLBkYK6c3zXpECMkZ0VzfbnYGFnWQ9xOly0XibiceTVGKdMJVAbX2TEz9Yt6uxvvJQ/0, createdBy=a8411981495, createdName=1e183db5m33(暂无匿称), createdTime=Wed Dec 14 22:32:26 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162515, encodeId=c71e162515d3, content=相关帕金森, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160807/IMG57A72B38A8C787546.jpg, createdBy=52b31714117, createdName=Anima, createdTime=Tue Dec 13 18:56:03 CST 2016, time=2016-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=162399, encodeId=acef16239940, content=思路很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19061994286, createdName=1e1b1150m51(暂无匿称), createdTime=Tue Dec 13 10:01:43 CST 2016, time=2016-12-13, status=1, ipAttribution=)]
    2016-12-13 1e1b1150m51(暂无匿称)

    思路很好

    0

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