Heart:瑞典地区23年间心肌梗死后的生存性别差异调查!

2017-08-09 MedSci MedSci原创

近期,一项发表在杂志Heart上的全国性研究中,研究者们调查了急性心肌梗死(AMI)后生存性别差异的年龄特异性和性别特征趋势,此项研究的受试人群包括了在医院外发生的冠心病(CHD)死亡。此项研究在瑞典进行,为观察性研究,研究对象为1987-2010年间年龄在35-84岁的658110名首次发生CHD事件的患者(35.7%的女性)。此项研究结果显示:年龄调整的28天病例死亡率由23.5%下降至8.5

近期,一项发表在杂志Heart上的全国性研究中,研究者们调查了急性心肌梗死(AMI)后生存性别差异的年龄特异性和性别特征趋势,此项研究的受试人群包括了在医院外发生的冠心病(CHD)死亡。


此项研究在瑞典进行,为观察性研究,研究对象为1987-2010年间年龄在35-84岁的658110名首次发生CHD事件的患者(35.7%的女性)。

此项研究结果显示:年龄调整的28天病例死亡率由23.5%下降至8.5%(p <0.05)。在住院病例中,与同龄男性相比,年龄在35-54岁之间的女性的短期生存率较差;35-54岁女性相对于男性的HR为1.63(95%CI为1.28〜2.08),55-64岁为1.28(95%CI为1.12〜1.46)(2005年至2010年);但在调整合并症后,男女之间的差异不再显着(HR 1.25(95%CI 为0.97〜1.61)和1.05(95%CI 为0.91〜1.20))。

当包括医院外的CHD死亡病人时,无论年龄和时间段,女性的预后都较好。在前28天存活的患者中,男性和女性的年龄调整后的1年死亡率均从15.3%下降到7.7%(p <0.05)。调整合并症后,75岁以下患者的性别差异无显着性差异。75-84岁女性的28天幸存者与老年男性相比预后更好。

此项研究结果表明:调整合并症后,年龄小于55岁的住院女性AMI患者短期较差的结果并未持续。当包括医院外的CHD死亡病人时,女性的短期预后一直较好。当合并症的差异被考虑时,在28天的幸存者中,女性患者并不比男性更差。

原始出处:
Berg J, Björck L, et al. Sex differences in survival after myocardial infarction in Sweden, 1987-2010. Heart. 2017 Aug 7. pii: heartjnl-2016-310281. doi: 10.1136/heartjnl-2016-310281. 

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    2017-08-11 zhaojie88
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    2017-08-11 slcumt
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    2017-08-09 1e0f8808m18(暂无匿称)

    学习了,感谢分享。

    0

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    2017-08-09 楠博One

    学习谢谢分享

    0

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