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Sci Signal：调控肥大细胞脱颗粒过程的信号通路

2018-07-09 学术经纬 学术经纬

tomosyn-1tomosyn-1过敏
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嗜碱性粒细胞(basophils)和肥大细胞(mast cells)是身体中触发过敏反应和参与宿主免疫防御的免疫细胞。

嗜碱性粒细胞(basophils)和肥大细胞(mast cells)是身体中触发过敏反应和参与宿主免疫防御的免疫细胞。它们通过释放细胞内携带蛋白酶、脂类介导因子、细胞因子和组织胺(histamine)的分泌颗粒(secretory granule)来完成这些功能。细胞的脱颗粒(degranulation)过程需要分泌颗粒与细胞膜融合，这个过程受到SNARE家族蛋白的严密调控。法国巴黎的炎症研究中心(Centre de Recherche sur l’Inflammation)的研究人员对介导脱颗粒过程的信号通路进行了研究。他们发现名为tomosyn-1的SNARE结合蛋白能够在肥大细胞中起到抑制脱颗粒过程的作用。而tomosyn-1抑制脱颗粒的作用基于PKCδ对它的磷酸化。 细胞外IgE水平升高会提高tomosyn-1的表达水平。同时研究人员发现那些血清中IgE水平升高的过敏患者的嗜碱性粒细胞表达的tomosyn-1水平也会升高。这项研究证明了tomosyn-1是一个抑制肥大细胞脱颗粒过程的调节因子。在过敏患者中tomosyn-1水平的升高可能是患者限制疾病发展和过敏症状的反馈机制。

原始出处：

Iris K. Madera-Salcedo，et al.Tomosyn functions as a PKCδ-regulated fusion clamp in mast cell degranulation.Sci Signal.03 Jul 2018：Vol. 11， Issue 537， eaan4350

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    2019-03-31 楚秀娟

    #Sign#

    0

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    2018-09-27 yaanren

    #Signal#

    0

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    2018-07-11 智者为医08

    #信号通路#

    0

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    2018-07-11 gds2014

    #肥大细胞#

    0

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    2018-07-09 kafei

    学习了谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2036187, encodeId=840d203618ec4, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Sun Mar 31 02:17:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794007, encodeId=39fa1e9400766, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Thu Sep 27 04:17:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539686, encodeId=278d1539686c0, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Jul 11 04:17:00 CST 2018, time=2018-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569183, encodeId=5bf71569183b5, content=<a href='/topic/show?id=13288188450' target=_blank style='color:#2F92EE;'>#肥大细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81884, encryptionId=13288188450, topicName=肥大细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c92315497125, createdName=gds2014, createdTime=Wed Jul 11 04:17:00 CST 2018, time=2018-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330391, encodeId=9ea23303910f, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Mon Jul 09 17:14:51 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330386, encodeId=9d54330386f5, content=不错的文章值得拥有哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Mon Jul 09 14:48:14 CST 2018, time=2018-07-09, status=1, ipAttribution=)]
    2018-07-09 1e1b8538m79(暂无匿称)

    不错的文章值得拥有哦

    0