JAMA Network Open:颠覆认知,10年随访研究表明,适量饮酒可以保护大脑功能,提高认知能力

2020-10-04 生物世界 Bio生物世界

酒精饮料是最重要的饮品之一,在全世界范围内有近20亿名消费者,许多研究已经证实,酗酒会诱发心脑血管疾病、代谢性疾病,甚至于某些癌症的发生也与饮酒密切相关。

酒精饮料是最重要的饮品之一,在全世界范围内有近20亿名消费者,许多研究已经证实,酗酒会诱发心脑血管疾病、代谢性疾病,甚至于某些癌症的发生也与饮酒密切相关。

而对于喝酒脸红的人来说(主要是亚洲人群),他们是携带了ALDH2基因突变,导致酒精代谢物——乙醛的大量积累,从而引起人体对毒素的反应,即皮肤潮红和发炎。这些人即使只是喝少量饮酒,患上胃癌的风险也会大大增加。详情:喝酒脸红的人,患胃癌风险大增,他们都有同一个基因突变

除了饮酒对身体健康方面的影响之外,有些研究则聚焦在饮酒对认知障碍和老年痴呆的发展中的作用,然而这些研究结论相互矛盾,有些研究报告了少量或适度饮酒对大脑认知功能有好处,有些研究则发现饮酒对大脑认知功能几乎没有影响。

近日,美国佐治亚大学公共卫生学院的研究人员在 JAMA 子刊 JAMA Network Open 杂志上发表题为:Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults 的研究论文。

该研究调查了中老年人饮酒与认知功能随时间变化之间的关系,并表明少量或适量饮酒可以保护老年人的大脑功能。

有研究表明有规律的、适度的饮酒对大脑健康有一定保护作用,然而,这些研究大多数不是为了区分酒精对认知能力的影响而设计,也没有测量酒精长时间的影响。

在这项研究中,研究团队设计了一种方法,利用来自全国的、有代表性的健康和退休参与者的研究数据,来追踪他们长达10年的认知能力变化。研究共有19887名参与者,每两年完成一次关于他们的健康和生活方式的调查,包括有关饮酒习惯的问题。

轻度至中度饮酒的定义是——女性每周饮酒少于8杯,男性每周饮酒少于15杯。与此同时,这些参与者的认知功能也在一系列测试中得到了测量,包括考察他们的整体精神状态、单词记忆和词汇量,他们的测试结果会被组合成一个认知总分。

研究小组观察到这些参与者的认知总分随时间的变化并不一致,有的人会持续获得高分,有些则表现为逐渐下降。他们发现,与不饮酒者相比,那些每天喝一两杯酒的人随着时间的推移在认知测试中的表现往往更好,得分更高。

更重要的是,这一结果是严谨可靠的,即使控制了其他已知的、影响认知的重要因素,如年龄、吸烟或受教育程度,结果仍表明轻度饮酒与高认知能力相关。值得注意的是,少量或适量饮酒的白人参与者表现得与总认知功能下降的年发生率降低有关,而在黑人参与者中,这种联系较弱。

对此,论文第一作者Ruiyuan Zhang说道:“我们的研究表明少量或适量饮酒可以保护中老年人的认知能力,但很难说这种影响是因果关系。所以,如果有些人原本不喝,我们不鼓励他们喝酒来防止认知功能衰退。”

总而言之,这项研究表明少量或中度饮酒与较好的认知得分有关,而且这种关联在白人参与者中比黑人参与者更明显。研究小组表示会进一步对中老年人饮酒与认知之间关联的机制进行研究。

原始出处:

Ruiyuan Zhang, Luqi Shen, Toni Miles,et al.Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults.JAMA Netw Open. 2020 Jun 1;3(6):e207922. doi: 10.1001/jamanetworkopen.2020.7922.

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    2021-09-19 医者仁者

    #饮酒#小酌怡情大饮伤身

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    2021-04-09 canlab
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    2021-05-18 habb
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    2020-11-30 feather89
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    2020-10-04 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1053085, encodeId=44db105308537, content=<a href='/topic/show?id=c37e1012082d' target=_blank style='color:#2F92EE;'>#饮酒#</a>小酌怡情大饮伤身, beContent=null, objectType=article, channel=null, level=null, likeNumber=150, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101208, encryptionId=c37e1012082d, topicName=饮酒)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=医者仁者, createdTime=Sun Sep 19 20:07:42 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903591, encodeId=f97319035915d, content=<a href='/topic/show?id=d386438e55a' target=_blank style='color:#2F92EE;'>#大脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43875, encryptionId=d386438e55a, topicName=大脑功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Sun Nov 08 08:18:29 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734261, encodeId=b09b1e34261ed, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Fri Apr 09 01:18:29 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1716556, encodeId=db911e165567f, content=<a href='/topic/show?id=afa5984e47a' target=_blank style='color:#2F92EE;'>#随访研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98474, encryptionId=afa5984e47a, topicName=随访研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c1232248438, createdName=habb, createdTime=Tue May 18 15:18:29 CST 2021, time=2021-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728679, encodeId=4f831e286793e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Nov 30 08:18:29 CST 2020, time=2020-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442448, encodeId=d2d1144244870, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Tue Oct 06 03:18:29 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490060, encodeId=b3291490060c9, content=<a href='/topic/show?id=254794e30b0' target=_blank style='color:#2F92EE;'>#适量饮酒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94730, encryptionId=254794e30b0, topicName=适量饮酒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Tue Oct 06 03:18:29 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036292, encodeId=24fc1036292a3, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sun Oct 04 15:18:29 CST 2020, time=2020-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=890059, encodeId=679389005962, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Oct 04 12:39:55 CST 2020, time=2020-10-04, status=1, ipAttribution=)]
    2020-10-04 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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本研究为了验证多发性硬化病程中加速认知功能损害的病理过程,利用纵向MRI进行研究,其对复发缓解型MS(RRMS)和进展性MS(PMS)的认知下降具有诊断意义。

JAMA Netw Open :中国科学家团队研究,睡太多,或太少,都与认知下降有关

睡眠是我们每个人赖以生存的续命行为,因为不睡觉会死(不信你看:Cell解谜:不睡觉真的会死!但致死的变化不是发生在大脑,而是肠道...)。

Diabetes Care:二甲双胍与2型糖尿病老年人认知能力和痴呆症风险相关

接受二甲双胍治疗的老年糖尿病患者认知能力下降较慢,痴呆症风险较低。在患有和没有糖尿病的人群中进行的大规模随机研究将确定这些关联是否可归因于二甲双胍。