JNCI：维生素E或可降低患肝癌风险

近日，刊登在国际杂志Journal of the National Cancer Institute上的一篇研究报告指出，来自于饮食或者单纯维生素E的摄入可以降低肝癌患病风险。肝癌是世界上第三大常见的癌症死亡疾病，将近85%的肝癌发生在发展中国家，在中国占到了54%。很多流行病学调查了维生素E的摄入和肝癌的关系，然而众多结果并不一致。

为了确定维生素E的摄入和肝癌风险的关系，来自上海癌症研究中心等机构的研究者分析了中国132，837个个体的数据，这些个体来自于上海妇女健康（SWHS）和上海男性健康（SMHS）的研究机构。分析有效的饮食频率的调查问卷，研究者记录了参与者平时的膳食习惯，他们比较了高摄入维生素E和低摄入维生素E的参与者的肝癌风险相关数据。、

研究者的分析数据中包括了267个肝癌病人，包括118个女性和149个男性，结果表明饮食或者单纯的维生素E摄入都和低的肝癌风险直接相关。而且这种结果不因个体后天患肝癌或者家族遗传的肝癌而变化。总的来说，在中国，高剂量的维生素E摄入与中老年人低的肝癌风险直接相关。

编译自：Vitamin E May Lower Liver Cancer Risk

doi:10.1093/jnci/djs277
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Vitamin Intake and Liver Cancer Risk: A Report From Two Cohort Studies in China

Wei Zhang, Xiao-Ou Shu, Honglan Li, Gong Yang, Hui Cai, Bu-Tian Ji, Jing Gao, Yu-Tang Gao, Wei Zheng and Yong-Bing Xiang

Correspondence to: Xiao-Ou Shu, MD, PhD, Vanderbilt Epidemiology Center, 2525 West End Ave, Ste 600 (IMPH), Nashville, TN 37203-1738 (e-mail: xiao-ou.shu@vanderbilt.edu) and Yong-Bing Xiang, MD, MSc, Shanghai Cancer Institute, No. 25, Lane 2200, Xie Tu Road, Shanghai 200032, People’s Republic of China (e-mail: ybxiang@shsci.org).Background Epidemiologic studies on the relationship between vitamin intake and liver cancer risk are sparse and inconsistent. Methods We evaluated vitamin intake from diet and supplements and risk of liver cancer in 132 837 women and men from China who were recruited into the Shanghai Women’s Health Study from 1997 to 2000 or the Shanghai Men’s Health Study from 2002 to 2006. In-person interviews, using a validated food-frequency questionnaire, were conducted to collect data on dietary habits. Follow-up consisted of in-person surveys and record linkage. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazard models with adjustment for potential confounders to compare liver cancer risk among participants with high vs low vitamin intake. All statistical tests were two-sided. Results After excluding the first 2 years of follow-up, 267 participants (including 118 women and 149 men) developed liver cancer during an average of 10.9 (Shanghai Women’s Health Study) or 5.5 (Shanghai Men’s Health Study) years of follow-up. Dietary vitamin E intake was inversely associated with liver cancer risk (P trend = .01), as was vitamin E supplement use (hazard ratio = 0.52, 95% confidence interval = 0.30 to 0.90). This association was consistent among participants with and without self-reported liver disease or a family history of liver cancer. Vitamin C and multivitamin use was associated with increased risk among participants with self-reported liver disease or family history of liver cancer, whereas intake of vitamin C and other vitamins from dietary sources was unrelated to liver cancer risk. Conclusions Vitamin E intake, either from diet or supplements, may reduce the risk of liver cancer.