“超级细菌”MRSA的克星来了 存在南极海绵中

2016-06-26 环球网 环球网

近日,研究者在一种南极海绵动物中发现了一种物质,该物质可以有效杀灭98%的耐药超级菌——耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA),目前该菌在美国快速传播。随着越来越多的细菌对目前使用的抗生素产生耐药性,科学家正在极力地寻找可以抵御这些病菌的物质,这 项研究发现的存在于南极海绵中的一种物质可能是其中的一个选择。

近日,研究者在一种南极海绵动物中发现了一种物质,该物质可以有效杀灭98%的耐药超级菌——耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA),目前该菌在美国快速传播。随着越来越多的细菌对目前使用的抗生素产生耐药性,科学家正在极力地寻找可以抵御这些病菌的物质,这 项研究发现的存在于南极海绵中的一种物质可能是其中的一个选择。



金黄色葡萄球菌感染是很常见的感染,特别是在医院环境中。在正常情况下,这种病菌不是个难治的对象。但是MRSA是一株发展为对目前大部分抗生素耐药的菌株,也就说,这种病菌可以从皮表感染迅速蔓延,从而危及生命。

根据美国疾病控制与预防中心(CDC)的估计,美国每年有80000人被诊断为MRSA感染,大约有11000人死于MRSA并发症。目前,医生根本没有很多的方法可以有效治疗这种感染。

因此,这种物质的发现让研究者很振奋,这种物质被命名为“darwinolide”,存在于一种名为Dendrilla membranosa南极海绵动物中。目前在实验室的数据显示,darwinolide可杀灭98.4%的MRSA。

研究者已经对这种物质申请了专利,不过仍然在研究这种物质发挥作用的机制。最新的研究结果显示,这种物质有一种非常特别的结构,使得这种物质很容易渗透到MRSA细胞内,从而发挥杀菌作用。

下一步,研究者希望能在实验室合成darwinolide,这样就不用从南极海绵中提取darwinolide。接下来研究者打算在临床试验中测试这种物质的灭菌效果,如果有效,那么darwinolide可以拯救成千上万的患者生命。

原始出处:

Scientists just found a compound that kills 98% of a drug-resistant bacteria



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    2016-06-29 医路开来

    找到一种解救药物,我们就会破坏一中抗生素。以后就会变成无敌细菌。最好的办法是不要滥用抗生素。

    0

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  5. 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createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91246, encodeId=4cfc91246b6, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91233, encodeId=ed2191233e5, content=会不会产生新的耐药问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5rqTiaMSVSkFAupcTECOTdcVRmJQXbibJoicv5ibhcpa0vj5MGmac8wlPjuGnJISZGtOnC7rW0gbLuSE7iaEvAn0CC52ZhnRLdxtlQ/0, createdBy=1e291737907, createdName=1df01bccm39(暂无匿称), createdTime=Mon Jun 27 07:25:00 CST 2016, time=2016-06-27, status=1, ipAttribution=)]
    2016-06-28 吴教授

    希望尽快能研究出此药物的作用机制

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Jun 27 12:09:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91303, encodeId=b0c9913032d, content=是破坏MRSA的耐药机制吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Jun 27 10:22:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91245, encodeId=9fe491245c5, content=这个很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdBy=1e291737907, createdName=1df01bccm39(暂无匿称), createdTime=Mon Jun 27 07:25:00 CST 2016, time=2016-06-27, status=1, ipAttribution=)]
    2016-06-27 忠诚向上

    很好,有救

    0

  7. 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    2016-06-27 JBY

    是破坏MRSA的耐药机制吗

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12243, encryptionId=ccc412243db, topicName=MRSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Tue Jun 28 11:51:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91406, encodeId=7c1f91406ac, content=希望尽快能研究出此药物的作用机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue Jun 28 07:32:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91318, encodeId=daab91318bf, content=很好,有救, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Jun 27 12:09:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91303, encodeId=b0c9913032d, content=是破坏MRSA的耐药机制吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Jun 27 10:22:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91245, encodeId=9fe491245c5, content=这个很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91246, encodeId=4cfc91246b6, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91233, encodeId=ed2191233e5, content=会不会产生新的耐药问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5rqTiaMSVSkFAupcTECOTdcVRmJQXbibJoicv5ibhcpa0vj5MGmac8wlPjuGnJISZGtOnC7rW0gbLuSE7iaEvAn0CC52ZhnRLdxtlQ/0, createdBy=1e291737907, createdName=1df01bccm39(暂无匿称), createdTime=Mon Jun 27 07:25:00 CST 2016, time=2016-06-27, status=1, ipAttribution=)]
    2016-06-27 milkshark

    这个很好

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2054852, encodeId=0313205485203, content=<a href='/topic/show?id=250012241d8' target=_blank style='color:#2F92EE;'>#mRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12241, encryptionId=250012241d8, topicName=mRS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Mon Aug 29 21:51:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91583, encodeId=3f4d91583e4, content=找到一种解救药物,我们就会破坏一中抗生素。以后就会变成无敌细菌。最好的办法是不要滥用抗生素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12243, encryptionId=ccc412243db, topicName=MRSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce072500140, createdName=12498b3em08(暂无昵称), createdTime=Tue Jun 28 11:51:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91406, encodeId=7c1f91406ac, content=希望尽快能研究出此药物的作用机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue Jun 28 07:32:00 CST 2016, time=2016-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91318, encodeId=daab91318bf, content=很好,有救, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Jun 27 12:09:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91303, encodeId=b0c9913032d, content=是破坏MRSA的耐药机制吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Jun 27 10:22:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91245, encodeId=9fe491245c5, content=这个很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91246, encodeId=4cfc91246b6, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91233, encodeId=ed2191233e5, content=会不会产生新的耐药问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5rqTiaMSVSkFAupcTECOTdcVRmJQXbibJoicv5ibhcpa0vj5MGmac8wlPjuGnJISZGtOnC7rW0gbLuSE7iaEvAn0CC52ZhnRLdxtlQ/0, createdBy=1e291737907, createdName=1df01bccm39(暂无匿称), createdTime=Mon Jun 27 07:25:00 CST 2016, time=2016-06-27, status=1, ipAttribution=)]
    2016-06-27 milkshark

    的确不错

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Jun 27 12:09:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91303, encodeId=b0c9913032d, content=是破坏MRSA的耐药机制吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b711667381, createdName=JBY, createdTime=Mon Jun 27 10:22:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91245, encodeId=9fe491245c5, content=这个很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91246, encodeId=4cfc91246b6, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Mon Jun 27 07:48:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91233, encodeId=ed2191233e5, content=会不会产生新的耐药问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM5rqTiaMSVSkFAupcTECOTdcVRmJQXbibJoicv5ibhcpa0vj5MGmac8wlPjuGnJISZGtOnC7rW0gbLuSE7iaEvAn0CC52ZhnRLdxtlQ/0, createdBy=1e291737907, createdName=1df01bccm39(暂无匿称), createdTime=Mon Jun 27 07:25:00 CST 2016, time=2016-06-27, status=1, ipAttribution=)]
    2016-06-27 1df01bccm39(暂无匿称)

    会不会产生新的耐药问题

    0

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