Am J Cardiol:左主冠状动脉明显狭窄血管重建术后出院后房颤的发生率及预后影响

2020-08-12 MedSci原创 MedSci原创

左主冠状动脉疾病(LMCAD)经皮冠状动脉介入治疗(PCI)和冠状动脉搭桥术(CABG)后出院后,房颤或扑动(AF)的发生率、复发率和预后意义尚不清楚。本研究旨在确定接受PCI或CABG治疗的LMCA

左主冠状动脉疾病(LMCAD)经皮冠状动脉介入治疗(PCI)和冠状动脉搭桥术(CABG)后出院后,房颤或扑动(AF)的发生率、复发率和预后意义尚不清楚。本研究旨在确定接受PCI或CABG治疗的LMCAD患者出院后房颤的3年发生率和临床影响。

 

在EXCEL试验中,1,905名LMCAD患者随机接受PCI与CABG治疗。研究人员分析了3年内出院后心房颤动的发生情况及其与不良结局的时间校正关系。

 

共有1,802名基线时无AF的患者组成了研究队列。在3年内,227例房颤发生(PCI组29例[12.8%],CABG组198例[87.2%],p <0.0001);其中,57名患者的63次(27.7%)发生在出院后。院内房颤可预测出院后房颤(危险比[HR]2.94,95%置信区间[CI]1.42~6.10,p = 0.004)。多变量分析显示,时间更新的出院后AF是3年血管死亡(HR 4.91,95% CI 1.92~12.60,p = 0.0009)、卒中(HR 4.87,95% CI 1.12~21.12,p = 0.035)以及死亡、卒中或心肌梗死的复合结局(HR 3.09,95% CI 1.56~3.6~6.11,p = 0.001)的独立预测因子。在出院后AF患者中,主要复合结局的发生率并不因有无院内AF而变化(21.0% vs 23.8%,p = 0.78)。

 

总之,该研究结果表明,LMCAD的CABG或PCI术后出院后AF与死亡率和卒中增加相关。院内房颤是出院后AF的独立预测因素。

 

原始出处:

 

Ioanna KosmidouYangbo Liu, et al., Incidence and Prognostic Impact of Atrial Fibrillation After Discharge Following Revascularization for Significant Left Main Coronary Artery Narrowing. Am J Cardiol. 2020 Feb 15;125(4):500-506. doi: 10.1016/j.amjcard.2019.11.021. 

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    2020-08-12 神盾医疗局局长Jack

    该研究结果表明,LMCAD的CABG或PCI术后出院后AF与死亡率和卒中增加相关。院内房颤是出院后AF的独立预测因素。

    0

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    2020-08-12 钻子,锤子,锯子

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1782094, encodeId=83431e820944f, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Sep 20 09:59:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826626, encodeId=ae86182662696, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Feb 22 06:59:14 CST 2021, time=2021-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807690, encodeId=82b180e690e4, content=该研究结果表明,LMCAD的CABG或PCI术后出院后AF与死亡率和卒中增加相关。院内房颤是出院后AF的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Wed Aug 12 09:37:48 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807629, encodeId=b7e180e62903, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c59f5403928, createdName=钻子,锤子,锯子, createdTime=Wed Aug 12 09:15:17 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807628, encodeId=125280e628a7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Aug 12 09:15:14 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031293, encodeId=cd7810312933c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Aug 12 03:59:14 CST 2020, time=2020-08-12, status=1, ipAttribution=)]
    2020-08-12 飞翔的乌龟

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1782094, encodeId=83431e820944f, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sun Sep 20 09:59:14 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826626, encodeId=ae86182662696, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Feb 22 06:59:14 CST 2021, time=2021-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807690, encodeId=82b180e690e4, content=该研究结果表明,LMCAD的CABG或PCI术后出院后AF与死亡率和卒中增加相关。院内房颤是出院后AF的独立预测因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Wed Aug 12 09:37:48 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807629, encodeId=b7e180e62903, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c59f5403928, createdName=钻子,锤子,锯子, createdTime=Wed Aug 12 09:15:17 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807628, encodeId=125280e628a7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Aug 12 09:15:14 CST 2020, time=2020-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031293, encodeId=cd7810312933c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Wed Aug 12 03:59:14 CST 2020, time=2020-08-12, status=1, ipAttribution=)]
    2020-08-12 心介

    房颤,临床上碰到很多哦

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