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DEV CELL：血管微环境通过klf6a-ccl25b调节造血干细胞和祖细胞储存和扩增

2017-08-14 MedSci MedSci原创

血管微环境
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在造血干细胞发育的不同阶段，都有特定的微环境对其进行调控。近日，国际杂志 《DEV CELL》在线发表一项关于微环境如何调控造血干细胞扩增的研究。研究人员描述斑马鱼尾部造血组织（CHT），并确定HSPC扩张的重要细胞和分子机制。

在造血干细胞发育的不同阶段，都有特定的微环境对其进行调控。近日，国际杂志 《DEV CELL》在线发表一项关于微环境如何调控造血干细胞扩增的研究。研究人员描述斑马鱼尾部造血组织（CHT），并确定HSPC扩张的重要细胞和分子机制。 研究人员利用斑马鱼体外发育和早期胚胎透明的优势，通过激光共聚焦显微镜实时观察，发现尾部造血组织处的造血干细胞毗邻于血管内皮细胞，并且其迁移和扩增具有尾部静脉特异的方向性。延时成像显示HSPCs定位在血管内皮细胞（ECs）附近，并且它们的迁移和扩张显示了CHT中的尾静脉特异性取向。RNA测序和功能分析发现EC表达的转录因子Krüppel样因子6a（Klf6a）对于CHT生态位是至关重要的。进一步证明Klf6a直接调节趋化因子（CC基序）配体25b的表达，以调节HSPC分泌和增殖。体外培养结果支持Ccl21 / Ccr7信号传导在哺乳动物HSPC扩增中的保守作用。 研究提示尾部血管内皮细胞是造血干细胞微环境中的重要因素。确定了Klf6a-Ccl25b / Ccr7轴在控制复合HSPC-CHT生物相互作用中的功能，这可能适用于移植后体外扩增或植入HSPC。 原始出处

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    2018-03-16 zhaozhouchifen

    #Cell#

    0

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    2018-04-25 charl1234567

    #CCL2#

    0

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    2017-09-03 fzwish20000

    #Dev#

    0

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    2017-09-09 维他命

    #CEL#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1870118, encodeId=52d118e011812, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Mar 16 07:35:00 CST 2018, time=2018-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991477, encodeId=69c519914e75d, content=<a href='/topic/show?id=78e4421227' target=_blank style='color:#2F92EE;'>#CCL2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4212, encryptionId=78e4421227, topicName=CCL2)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Wed Apr 25 13:35:00 CST 2018, time=2018-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1982262, encodeId=9dd41982262ae, content=<a href='/topic/show?id=13b658e849' target=_blank style='color:#2F92EE;'>#Dev#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5878, encryptionId=13b658e849, topicName=Dev)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bcaa382, createdName=fzwish20000, createdTime=Sun Sep 03 05:35:00 CST 2017, time=2017-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960378, encodeId=c90619603e8dd, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Sep 09 03:35:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1271411, encodeId=552312e141193, content=<a href='/topic/show?id=a0ff950018f' target=_blank style='color:#2F92EE;'>#造血干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95001, encryptionId=a0ff950018f, topicName=造血干细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e729101, createdName=huanbaofeng, createdTime=Wed Aug 16 10:35:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494556, encodeId=6da214945561f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Wed Aug 16 10:35:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512424, encodeId=486d1512424c5, content=<a href='/topic/show?id=f802e4102cb' target=_blank style='color:#2F92EE;'>#祖细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74102, encryptionId=f802e4102cb, topicName=祖细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f18310470858, createdName=12498636m52(暂无昵称), createdTime=Wed Aug 16 10:35:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233689, encodeId=91ca2336899d, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Tue Aug 15 06:42:21 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=233645, encodeId=09a423364562, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Tue Aug 15 05:35:21 CST 2017, time=2017-08-15, status=1, ipAttribution=)]
    2017-08-16 huanbaofeng

    #造血干细胞#

    0

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    2017-08-16 俅侠

    #造血#

    0

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    2017-08-16 12498636m52(暂无昵称)

    #祖细胞#

    0

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    2017-08-15 刘煜

    学习了谢谢分享

    0

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    2017-08-15 清风拂面

    谢谢分享学习了

    0