Coron Artery Dis：糖化血红蛋白水平可能提示糖尿病合并STEMI心血管事件风险上升

2015-05-05 范伟译 MedSci原创

背景：最近的研究表明连续控制糖尿病对ST段抬高心肌梗死(STEMI)患者的有利结果是重要的。本研究旨在评估对冠状动脉再灌注后糖尿病合并STEMI的患者栓塞后糖化血红蛋白(HbA1c)水平对主要不良心血管反应(MACE)的临床影响。患者和方法：总共有303名糖尿病合并STEMI的进行经皮冠状动脉介入治疗的患者参与本研究。所有符合条件的患者基于后续的糖化血红蛋白(FU-HbA1c)水平被分

背景：最近的研究表明连续控制糖尿病对ST段抬高心肌梗死(STEMI)患者的有利结果是重要的。本研究旨在评估对冠状动脉再灌注后糖尿病合并STEMI的患者栓塞后糖化血红蛋白(HbA1c)水平对主要不良心血管反应(MACE)的临床影响。

患者和方法：总共有303名糖尿病合并STEMI的进行经皮冠状动脉介入治疗的患者参与本研究。所有符合条件的患者基于后续的糖化血红蛋白(FU-HbA1c)水平被分成以下三个组，根据以下85天的中位数进行测量：最优，FU-HbA1c < 7%；次最优的，7%≤FU-HbA1c < 9%；较差的，FU-HbA1c≥9%。我们分析了12个月累积不良心血管反应，定义为死亡率、非致死性心肌梗死和血管再生。此外，我们研究了FU-HbA1c水平作为不良心血管反应的预测因子。

结果：不良心血管反应的发病率在组间差异显著(6.4 vs 13.6 vs19.6%；P = 0.048)。此外，在每个连续组风险增加(风险比：1.00 vs 2.19 vs 3.68；P = 0.046)。每增加1% FU-HbA1c水平导致不良心血管反应的相对风险增加49.3%(风险比：1.266；P = 0.031)。匹配的FU-HbA1c水平和不良心血管反应的截止值是7.45%。

结论：本研究表明，糖尿病合并ST段抬高心肌梗死(STEMI)患者再灌注后早期糖化血红蛋白水平FU-HbA1c的高水平与增加的12个月不良心血管反应有关，表明再灌注后连续血清葡萄糖水平的控制对获得更好的临床结果是重要的。糖化血红蛋白水平FU-HbA1c似乎是预测临床结果的有用指标。

原始出处：

Ahn J1, Hong TJ, Park JS, Lee HW, Oh JH, Choi JH, Lee HC,Cha KS, Yun E, Jeong MH, Chae SC, Kim YJ, Hur SH, Seong IW,Jang YS, Cho MC, Kim CJ, Seung KB, Rha SW, Bae JH, Park SJ;Korea Working Group on Myocardial Infarction investigators.Clinical influence of early followup glycosylated hemoglobin levels on cardiovascular outcomes in diabetic patients with ST-segment elevation myocardial infarction after coronary reperfusion. Coron Artery Dis. 2015 Apr 29.

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2016-07-27 午夜星河

当然了

77 0
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2016-01-11 hukaixun

#血管事件#

18 0
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2015-12-20 budeshao

#Artery#

25 0
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2015-06-01 cmj8wellington

#Dis#

26 0
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2015-05-07 zhanfl

#心血管事件风险#

16 0
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2015-05-07 zhaojie88

#ART#

23 0
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2015-05-07 12498bb3m92(暂无昵称)

#STEM#

0 0
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2015-05-06 qingfengqishi5

糖化血红蛋白又有新的研究发现。

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