J Dent Res:定制3D打印生物陶瓷支架材料修复下颌骨缺损的研究

2017-10-14 lishiting MedSci原创

到目前为止,能够采用适当的机械强度将个性化形态的人造生物材料植入体种植至牙槽骨缺损处仍然是一项挑战。在这篇研究中,基于CT影像的3维(3D)打印技术可以利用生物陶瓷支架材料精确制作出巨形或微小的下颌骨缺损。

到目前为止,能够采用适当的机械强度将个性化形态的人造生物材料植入体种植至牙槽骨缺损处仍然是一项挑战。在这篇研究中,基于CT影像的3维(3D)打印技术可以利用生物陶瓷支架材料精确制作出巨形或微小的下颌骨缺损。为了在兔下颌牙槽骨缺损模型中原位评估材料底物对骨组织再生的影响,研究使用全新的、具有一定机械强度的10%镁替代硅灰石材料(Ca90%Mg10%SiO3; CSi-Mg10)制作植入体,随后将其植入至骨缺损处,并与常规的疏松多孔钙-磷酸盐和钙-硅酸盐生物陶瓷相比较,如:β-磷酸三钙(TCP), 硅灰石(CaSiO3; CSi)和白硅钙石(Bred)。最初的物理化学测试表明,CSi-Mg10支架材料拥有最大的空隙维度,然而由于在烧结过程中支架材料明显的线性收缩导致其孔隙率最低。与保守的可溶性TCP支架材料(失重~2%)和超快速溶解(Tris缓冲液中浸泡6 wk)精制CSi及Bred支架材料 (分别失重~12%和~14%)相比,CSi-Mg10支架在体外展现出较弱的生物可溶性和中度的失重水平,~7%。除此之外,CSi-Mg10具有可观的原始弯曲强度(31 MPa)以及在Tris缓冲液浸泡时

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    2018-08-06 redcrab
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    2018-08-13 xlysu
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    2017-10-16 lfcmxl
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    2017-10-16 珙桐
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