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Exp Hypertens：研究揭示酸中毒可减少血管钙化的机制

2018-03-16 MedSci MedSci原创

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血管钙化,如动脉硬化（其特征为中膜钙化）是慢性肾病（CKD）的严重并发症，导致CKD患者的心血管发病率和死亡率升高。在脉硬化进展过程中的一个重要步骤是血管平滑肌细胞（VSMCs）的转分化/钙化，类似于骨生成。代谢性酸中毒是CKD中常见的临床表现，可减少血管钙化。为了了解酸中毒的潜在调节机制，我们探究了酸中毒VSMC钙化是否涉及LTCC/Ca2+/Runx2通路的信号改变。在体内或体外测量血管钙化、

血管钙化,如动脉硬化（其特征为中膜钙化）是慢性肾病（CKD）的严重并发症，导致CKD患者的心血管发病率和死亡率升高。在脉硬化进展过程中的一个重要步骤是血管平滑肌细胞（VSMCs）的转分化/钙化，类似于骨生成。代谢性酸中毒是CKD中常见的临床表现，可减少血管钙化。为了了解酸中毒的潜在调节机制，我们探究了酸中毒VSMC钙化是否涉及LTCC/Ca2+/Runx2通路的信号改变。

在体内或体外测量血管钙化、钙含量、runt相关转录因子2（Runx2）、碱性磷酸酶（ALP）、L型钙通道（LTCC）β3亚基和钙内流。钙化结节和钙含量在血管钙化大鼠的主动脉切片或β-GP诱导的VSMCs中增加。Runx2和ALP活性表达明显升高，伴随着LTCCβ3亚基表达增加和钙内流。然而，酸中毒补充成功地减弱了VC和VSMC钙化，并且抑制了Runx2、AL、LTCCβ3亚基和钙内流。

总之，酸中毒可明显减少血管钙化与LTCC/Ca2+/Runx2通路下调有关。

原始出处：

Zhang S, Xu J, et al., Extracellular acidosis suppresses calcification of vascular smooth muscle cells by inhibiting calcium influx via L-type calcium channels. Clin Exp Hypertens. 2018 Feb 8:1-8. doi: 10.1080/10641963.2017.1384482. [Epub ahead of print]

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    2018-04-20 feather89

    #PE#

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    2018-12-25 12498ebem19暂无昵称

    #TENS#

    0

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    2019-01-01 hywen7335

    #酸中毒#

    0

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    2018-03-18 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

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    2018-03-18 mashirong

    #中毒#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1727159, encodeId=76c21e271594e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Apr 20 14:22:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038868, encodeId=464120388687f, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Dec 25 08:22:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676144, encodeId=15ee16e614443, content=<a href='/topic/show?id=6bac955861e' target=_blank style='color:#2F92EE;'>#酸中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95586, encryptionId=6bac955861e, topicName=酸中毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5dd27335710, createdName=hywen7335, createdTime=Tue Jan 01 20:22:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297503, encodeId=556429e503a3, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Mar 18 23:07:54 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319069, encodeId=c0031319069dc, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Mar 18 12:22:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296937, encodeId=760a29693ec3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Mar 17 00:57:49 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296927, encodeId=191229692e57, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Mar 17 00:12:24 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1727159, encodeId=76c21e271594e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Apr 20 14:22:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038868, encodeId=464120388687f, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Dec 25 08:22:00 CST 2018, time=2018-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1676144, encodeId=15ee16e614443, content=<a href='/topic/show?id=6bac955861e' target=_blank style='color:#2F92EE;'>#酸中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95586, encryptionId=6bac955861e, topicName=酸中毒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5dd27335710, createdName=hywen7335, createdTime=Tue Jan 01 20:22:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297503, encodeId=556429e503a3, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sun Mar 18 23:07:54 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319069, encodeId=c0031319069dc, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Mar 18 12:22:00 CST 2018, time=2018-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296937, encodeId=760a29693ec3, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat Mar 17 00:57:49 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=296927, encodeId=191229692e57, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Mar 17 00:12:24 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-17 飛歌

    厉害了我的哥

    0