JCEM:严重肥胖人群肝脏脂肪酸平衡与肝脏脂肪含量的关系

2019-08-14 xing.T MedSci原创

由此可见,在非糖尿病、严重肥胖的个体中,过量的肝内脂质与VLDL颗粒中甘油三酯的排出相关,而不是增加全身游离脂肪酸的摄取。

非酒精性脂肪肝可导致肝脏炎症/损伤。了解导致肝脏脂质过量积累的生理机制可能有助于确定有效的治疗方法。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究招募了25名计划进行减肥手术的严重肥胖、非糖尿病患者。

为了评估肝脏排出的甘油三酯-脂肪酸水平,研究人员在手术前一天使用自体[1-14C]三油酸甘油酯标记的VLDL颗粒的输注的方法测定了极低密度脂蛋白(VLDL)-甘油三酯分泌率,并使用空腹的酮体反应和肝内长链酰基肉碱浓度作为肝脏脂肪酸氧化的指标。研究人员使用连续输注[U-13C]棕榈酸酯,结合推注[9,10-3H]棕榈酸酯和仔细定时的肝脏活组织检查,测量了血浆游离脂肪酸的术中肝摄取率。在肝活组织检查样品中测量肝内总脂质量以确定脂肪肝状态。研究人员使用液相色谱/串联质谱法测量二酰基甘油、鞘脂和酰基肉碱中[U-13C]棕榈酸酯的肝浓度和富集情况。

在患有脂肪肝的参与者中,肝内脂质与VLDL-甘油三酯分泌率呈负相关(r=-0.92,P=0.01),但与肝脏游离脂肪酸摄取或肝脏脂肪酸氧化指数无关。VLDL-甘油三酯分泌率与肝脏饱和二酰基甘油(r = 0.46,P = 0.02)和鞘氨醇-1-磷酸(r = 0.44,P = 0.03)浓度呈正相关。

由此可见,在非糖尿病、严重肥胖的个体中,过量的肝内脂质与VLDL颗粒中甘油三酯的排出相关,而不是增加全身游离脂肪酸的摄取。 

原始出处:

Kelli A Lytle,et al.Hepatic Fatty Acid Balance and Hepatic Fat Content in Severely Obese Humans.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2019-00875

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    2019-08-24 achengzhao
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    2019-12-27 smallant2015
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    2019-08-15 329523732

    不错

    0

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