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Sci. Transl. Med.：利什曼原虫对血红素的渴望可用来制造新的疫苗

2013-09-12 EurekAlert!中文 EurekAlert!中文

利什曼原虫血红素疫苗
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利什曼原虫是世界上仅次于造成疟疾的疟原虫的最致命的寄生虫之一。这种寄生虫是通过雌性沙蝇的叮咬传播的，它会引起不同形式的利什曼病——这是一种以皮肤溃疡及内脏肿大为特征的疾病。利什曼病影响着全世界大约1200万人，然而还没有疫苗预防这种疾病，且用于治疗这种疾病的少数药物毒性很大、价格昂贵且容易产生耐药性。Rajan Guha及其同事在此显示，可以利用利什曼原虫对血红素的需要从而制造出一种针对这种寄生虫

利什曼原虫是世界上仅次于造成疟疾的疟原虫的最致命的寄生虫之一。这种寄生虫是通过雌性沙蝇的叮咬传播的，它会引起不同形式的利什曼病——这是一种以皮肤溃疡及内脏肿大为特征的疾病。利什曼病影响着全世界大约1200万人，然而还没有疫苗预防这种疾病，且用于治疗这种疾病的少数药物毒性很大、价格昂贵且容易产生耐药性。Rajan Guha及其同事在此显示，可以利用利什曼原虫对血红素的需要从而制造出一种针对这种寄生虫疾病的有效疫苗。血红素对利什曼原虫的生存是至关重要的，但是该寄生虫无法合成这种基于铁的分子。相反，利什曼原虫会从其宿主的血液中吸取血红蛋白并从中提取血红素。研究人员发现，阻断该寄生虫的宿主血红蛋白受体——一种叫做HbR的分子——可阻止这种寄生虫感染和造成伤害的能力。研究人员制造了一种针对HbR的疫苗并将其注射到啮齿动物体内。与未经治疗的动物相比，被治疗的动物几乎得到了完全的保护并在接触该寄生虫后不会得病。这些结果指出，HbR疫苗接种可成为一种保护机体不被利什曼原虫感染的新型武器。

原文阅读

Rajan Guha1, Deepika Gupta, Ruchir Rastogi, Rajagopal Vikram, Ganga Krishnamurthy, Sanjiva Bimal, Syamal Roy1,Amitabha Mukhopadhyay.Vaccination with Leishmania Hemoglobin Receptor–Encoding DNA Protects Against Visceral Leishmaniasis .Sci Transl Med2013 Sep 11.5(202):(121-202)

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    2014-03-28 ms3025846204744509

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    2014-03-31 bsmagic9140

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    2013-09-14 ms1692212821629096

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    2013-09-14 ms3994565386320060

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