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ACTA NEUROPATHOL ：路易体型痴呆（DLB）患者脑组织中的外来体促使α-突触核蛋白集聚的病理学研究

2017-06-12 xuyihan MedSci原创

Alzheimer’sdiseaseExosomesAlphasynuclein
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之前有研究报道已经证实，在包裹有外来体的细胞外囊泡中可以成功检测出参与神经变性疾病（如阿尔茨海默氏病（AD）和路易体型痴呆（DLB））的关键蛋白质，但是关于这种存在于DLB患者神经细胞中的外来体蛋白质是否可以向远端扩散的特性目前尚没有研究证实。

之前有研究报道已经证实，在包裹有外来体的细胞外囊泡中可以成功检测出参与神经变性疾病（如阿尔茨海默氏病（AD）和路易体型痴呆（DLB））的关键蛋白质，但是关于这种存在于DLB患者神经细胞中的外来体蛋白质是否可以向远端扩散的特性目前尚没有研究证实。

近期美国科学家进行了一项研究，他们首先获取了一些DLB和AD患者以及非患病患者的脑组织，然后通过对神经元细胞进行超速离心，成功收集患者的脑细胞外来体标本。我们已经知道，患有AD或DLB的患者脑中提取的外来体中是含有聚集体蛋白的，而研究人员将来自DLB患者的脑源性外来体注射到野生型小鼠的脑中后发现，DLB患者的脑源性外来体诱导了α-突触核蛋白（α-syn）的聚集。通过免疫荧光双标记检测后发现，在野生型小鼠的MAP2 +和Rab5 +神经元细胞中都出现了α-syn聚集现象。通过研究神经元细胞，研究人员还发现外来体介导的细胞内α-syn聚集是依赖于细胞内吞作用调控的。

最后，此项研究表明，来自DLB患者的脑源性外来体可以在体内扩散并且会促使α-syn在细胞内的聚集。

原始出处：


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    2018-05-06 longerg

    #路易体#

    0

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    2018-03-22 循证小兵

    #核蛋白#

    0

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    2018-03-16 yb6560

    #Pathol#

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-09-19 windight

    #CTA#

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-20 xuyihan

    学习了 不错吧

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, 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    2017-06-14 jktdtl

    #病理学#

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-14 ms691033630344116

    #突触#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-14 医者仁心

    #α-突触核蛋白#

    0

  9. 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channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue Sep 19 14:48:00 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213168, encodeId=105c213168a2, content=学习了 不错吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Tue Jun 20 18:17:21 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473435, encodeId=15d014e343550, content=<a href='/topic/show?id=4fd1e102257' target=_blank style='color:#2F92EE;'>#病理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71022, encryptionId=4fd1e102257, topicName=病理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8ce7226273, createdName=jktdtl, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478779, encodeId=533914e87793d, content=<a href='/topic/show?id=76efe555021' target=_blank style='color:#2F92EE;'>#突触#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75550, encryptionId=76efe555021, topicName=突触)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5207457717, createdName=ms691033630344116, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-14 yahu

    #脑组织#

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524513, encodeId=955d15245134f, content=<a href='/topic/show?id=f077191350d' target=_blank style='color:#2F92EE;'>#α-突触核蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19135, encryptionId=f077191350d, topicName=α-突触核蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592045, encodeId=cc1f159204549, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 14 04:48:00 CST 2017, time=2017-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=210062, encodeId=e0a52100622f, content=病理学研究资料珍贵, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Tue Jun 13 07:06:02 CST 2017, time=2017-06-13, status=1, ipAttribution=)]
    2017-06-13 baihao215

    病理学研究资料珍贵

    0

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