NEJM:广西研究人员证实脑干脑炎是危重症手足口病主要死因

2012-07-18 贺根生 中国科学报

      记者日前从广西医科大学获悉,该校第一附属医院儿科教授农光民带领团队,从全球病例数最多的一组临床病理资料中研究证实,并发严重的脑干脑炎是危重症手足口病死亡的主要原因,相关论文近日发表在《新英格兰医学杂志》上。      据悉,这是该杂志首次刊发广西研究人员的论文,也是中国大陆学者首次在该杂志上发

      记者日前从广西医科大学获悉,该校第一附属医院儿科教授农光民带领团队,从全球病例数最多的一组临床病理资料中研究证实,并发严重的脑干脑炎是危重症手足口病死亡的主要原因,相关论文近日发表在《新英格兰医学杂志》上。

     据悉,这是该杂志首次刊发广西研究人员的论文,也是中国大陆学者首次在该杂志上发表关于手足口病的研究文章。
农光民介绍说,手足口病是由肠道病毒引起的一种急性传染病,全球均有流行,其中EV71感染引起的手足口病病情往往较重,少数患儿病情凶险,易发生死亡。2008年以来,广西手足口病的发病率和危重症死亡率均居全国前几位。
目前,手足口病危重症的发病机制尚未完全明了,一直是国内外研究的热点。近年来,神经源性心肺功能衰竭被认为在手足口病危重症的发生发展中起主导作用,但有关研究资料十分有限,未能得到完全证实。
农光民系广西手足口病救治专家组组长,多年来他带领科研团队联合广西区内多家医院,一直致力于手足口病的临床研究。该团队通过多学科协作攻关,从全球病例数最多的一组临床病理资料研究证实,危重症手足口病死亡的主要原因是并发严重的脑干脑炎,而肺水肿、肺出血及心功能衰竭均为神经源性所致。
这一研究发现,对进一步阐明危重症手足口病的发病机理,进而指导临床救治具有重大的意义。
 
相关链接:Min Jiang, M.D.,Dan Wei, M.D.,Wei-Lin Ou, M.D.,Kun-Xiong Li, M.D.,Dian-Zhong Luo, M.D., Ph.D.,Yun-Qian Li, M.D.,E Chen, M.D.,Guang-Min Nong, M.D.,Ph.D.Autopsy Findings in Children with Hand, Foot, and Mouth Disease.N Engl J Med 2012;367:91-92.
 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1678309, encodeId=fc4b16e83096b, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sat Sep 22 14:39:00 CST 2012, time=2012-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907410, encodeId=a3f6190e41045, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sat Dec 01 17:39:00 CST 2012, time=2012-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343545, encodeId=9654134354582, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri Jul 20 04:39:00 CST 2012, time=2012-07-20, status=1, ipAttribution=)]
    2012-09-22 lingqf
  2. [GetPortalCommentsPageByObjectIdResponse(id=1678309, encodeId=fc4b16e83096b, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sat Sep 22 14:39:00 CST 2012, time=2012-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907410, encodeId=a3f6190e41045, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sat Dec 01 17:39:00 CST 2012, time=2012-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343545, encodeId=9654134354582, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri Jul 20 04:39:00 CST 2012, time=2012-07-20, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1678309, encodeId=fc4b16e83096b, content=<a href='/topic/show?id=256154569b3' target=_blank style='color:#2F92EE;'>#手足口#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54569, encryptionId=256154569b3, topicName=手足口)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbc627685059, createdName=lingqf, createdTime=Sat Sep 22 14:39:00 CST 2012, time=2012-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907410, encodeId=a3f6190e41045, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Sat Dec 01 17:39:00 CST 2012, time=2012-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1343545, encodeId=9654134354582, content=<a href='/topic/show?id=928a849314c' target=_blank style='color:#2F92EE;'>#脑炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84931, encryptionId=928a849314c, topicName=脑炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/22AEC2EC4805C29C6E1DEE6D888DB41C/100, createdBy=7a322500193, createdName=ms1779634646866130, createdTime=Fri Jul 20 04:39:00 CST 2012, time=2012-07-20, status=1, ipAttribution=)]