BMJ:长期麸质摄入与冠心病风险有关吗?

2017-05-04 xing.T MedSci原创

由此可见,长期摄入麸质与冠心病风险无关。然而,避免麸质可能会导致有益的全谷物摄入减少,这可能会影响心血管风险,在无乳糜泻的患者中不鼓励无麸质饮食。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在探讨长期摄入麸质与冠心病发生发展之间的关系。

该研究采用前瞻性队列研究设计,以64714名护士健康研究中的女性参与者和45303名健康专业随访研究中的无冠心病病史的男性参与者为基础,这些参与者在1986年完成了131项半定量食物频率问卷,并且每4年更新一次,直至2010年。研究人员通过食物频率问卷估计了麸质的摄入量。该研究的主要结局指标为冠心病(致死性或非致死性心肌梗死)的发生。

在26年的随访期间,共有2273931人次每年,其中2431名女性和4098名男性参与者患上了冠心病。相比于麸质的摄入量为最低第五名的参与者,其冠心病的发病率为352人每100000人每年,那些麸质的摄入量为最高第五名的参与者冠心病的发病率为277人每100000人每年,导致未经调整的发生率差异为75(95%可信区间为51-98)人每100000人每年。对已知的危险因素进行调整后,麸质的摄入量为最高第五名的参与者发生冠心病多变量的风险比为0.95(95%可信区间为0.88-1.02;趋势P=0.29)。对摄入全谷物进行额外的调整后,多元风险比为1(0.92-1.09;趋势P=0.77)。相反,对精制谷物摄入进行额外的调整后,估计的麸质摄入量与冠心病的风险降低相关(多元风险比为0.85,0.77-0.93;趋势P=0.002)。

由此可见,长期摄入麸质与冠心病风险无关。然而,避免麸质可能会导致有益的全谷物摄入减少,这可能会影响心血管风险,在无乳糜泻的患者中不鼓励无麸质饮食。

原始出处:

Benjamin Lebwohl,et al. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. BMJ 2017; http://www.bmj.com/content/357/bmj.j1892

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    2017-10-19 gaoxiaoe
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    2017-05-08 微笑人参

    粗粮,多元,维生素

    0

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    2017-05-06 1dd7d1dam20(暂无匿称)

    学习了有用。

    0

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    2017-05-05 jyzxjiangqin

    冠心病风险因素。

    0

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    2017-05-04 杨利洪

    学习了,我增加了知识

    0

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    2017-05-04 186****0580(小山羊)

    学习了谢谢了。

    0

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    2017-05-04 执着追梦

    学习,感谢分享!

    0

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