Scientific Reports:福兮祸兮?血糖高竟然防脑癌!

2017-05-05 佚名 转化医学网

最近,美国俄亥俄州立大学的一项研究进一步揭示了血糖和脑肿瘤之间惊人的关系,揭示了某些特定神经系统癌症的发展机制。


最近,美国俄亥俄州立大学的一项研究进一步揭示了血糖和脑肿瘤之间惊人的关系,揭示了某些特定神经系统癌症的发展机制。

研究人员发现,虽然糖尿病患者明显相对于健康人群更容易患上癌症,但神经胶质瘤在高血糖和糖尿病患者人群中却相对少见。这样看来,高血糖似乎降低了人们患上神经系统肿瘤的风险。

这两项由俄亥俄州综合癌症中心流行病学研究院Judith Schwartzbaum领导相关研究的对应文章发表在最新上线的Scientific Reports杂志上。

糖尿病和高血糖等症状可以增加诸如结肠癌乳腺癌和膀胱癌等癌症的发病风险,但在高血糖或糖尿病的情况下,更为罕见的恶性脑肿瘤却显得更难发生。” Schwartzbaum说。“我们的研究尚未完全阐明这一现象的内在分子机制,但我们相信对这一现象更为深入的研究将会使学术界更好地了解神经胶质瘤发展所涉及的各种分子机制。”

神经胶质瘤是起源于大脑的最常见恶性肿瘤之一。这种通常会被诊断于中年的恶性癌症目前还没有确定能够长期生存的治疗方法。

Scientific Reports杂志所报道的AMORIS和Me-Can项目总共涵盖了528,580名瑞典人和269,365名奥地利/瑞典人。两项研究对其中812名神经胶质瘤患者进行了深入调查。

Schwartzbaum及其合作者评估了这一人群血糖和糖尿病数据与脑癌发生之间的相关性,发现高血糖和糖尿病患者发生脑胶质瘤的风险相对健康人群更低。

“这一研究结果让我们非常惊诧,为什么血糖水平和脑癌之间的关系与其他几种肿瘤恰巧相反?” Schwartzbaum说。“我们猜测在某种程度上,这一结果可能表明肿瘤本身会影响患者的血糖水平,亦或高血糖或糖尿病症状可能与人类脑部肿瘤预防机制之间存在着一定更为深入的联系。”

“值得注意的是,大脑重量虽然只占人类总体重的2%左右,但消耗了身体可用葡萄糖20%。” Schwartzbaum补充说。

尽管这项研究已经体现了高血糖等相关症状对于脑癌发生的预防,但科学家仍需要更多的工作来确定血糖与神经系统肿瘤之间更为深入和具体的联系,以最终确定这种方法是否可以安全地应用于脑癌的预防方面。Schwartzbaum最终强调。

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    2017-05-07 jichang
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    2017-05-05 I come

    有意思,每件事情都有两面性

    0

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    2017-05-05 王秀

    有意思,凡事都有两面性!

    0

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    2017-05-05 dhzzm

    学习了分享了

    0

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    2017-05-05 ideal肿瘤医

    学习了有趣

    0

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